Gene interactions and pathways from curated databases and text-mining

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CTGF — PI3

Text-mined interactions from Literome

Suzuma et al., J Biol Chem 2000 : VEGF induced CTGF expression was mediated primarily by PI3-kinase activation, whereas PKC and ERK pathways made only minimal contributions
Utsugi et al., Am J Respir Cell Mol Biol 2003 : On the other hand, specific inhibitors of phosphatidylinositol 3-kinase (PI3K) suppressed TGF-beta1 induced CTGF expression in a concentration dependent manner
Xie et al., Am J Physiol Lung Cell Mol Physiol 2005 : We investigated the role of MAPKs and phosphatidylinositol 3-kinase (PI3K) and the effects of inflammatory cytokines on TGF-beta induced CTGF expression in human airway smooth muscle cells ( ASMC )
Wu et al., Kidney Int 2006 : CTGF enhanced the mRNA expression and protein release of fractalkine, MCP-1, and RANTES, the expression of phospho ( P ) -p42/44 mitogen activated protein kinase ( MAPK ), P-phosphoinositide 3-kinase (PI3-K) , P-Akt, and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells