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LDLR — LPA

Text-mined interactions from Literome

Snyder et al., J Biol Chem 1992 : At 4 degrees C, LDL receptor mediated binding of both Lp(a) and LDL was of low affinity, being 0.8 and 0.23 microM, respectively
Zawadzki et al., Biochemistry 1988 : Accordingly, the binding of the lipoproteins to the LDL receptor was also decreased in the presence of apo(a)
Snyder et al., Arterioscler Thromb 1994 : LDL receptor mediated degradation of 50 nmol/L Lp(a) in hepatocytes, macrophages, and fibroblasts was only 17 %, 22 %, and 26 %, respectively, of the value obtained with 50 nmol/L LDL and varied greatly among the cells in that it was lowest in hepatocytes, an order of magnitude greater in macrophages, and two orders of magnitude greater in fibroblasts ... Additionally, they show that there are great cellular differences in the LDL receptor mediated degradation of Lp(a) ... If these results can be extrapolated in vivo, where normal LDL levels are 40- to 50-fold higher than those of Lp(a), it would be unlikely that the hepatic LDL receptor is significantly involved in the degradation of Lp(a)
Schmidt et al., Blood Coagul Fibrinolysis 1993 (Coronary Disease...) : The effect of the cholesterol synthesis inhibitor on Lp(a) may be due to the upregulation of the LDL-receptor , suggesting a role for LDL receptor in Lp(a) catabolism