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ATP5O — EDN2
Text-mined interactions from Literome
Vaziri et al., J Hypertens Suppl 2002
(Hypertension) :
Several mechanisms have been shown to contribute to the pathogenesis of lead induced hypertension : ( 1 ) avid oxidation and inactivation of endogenous nitric oxide ( NO ) by reactive oxygen species leading to functional NO deficiency ; ( 2 ) increased sympathetic activity and circulating noradrenaline coupled with decreased vascular and elevated renal beta-adrenergic receptor density ; ( 3 ) increased angiotensin converting enzyme (ACE) activity and elevated plasma renin, angiotensin II and aldosterone levels ; ( 4 ) heightened kininase I and kininase II activities ; ( 5 ) possible increase in
endothelin and thromboxane production ; and ( 6 ) lead
mediated inhibition of vascular smooth muscle Na ( + ) -K+
ATPase leading to a rise in cellular Na+ and hence Ca2+ stores
Garvin et al., J Am Soc Nephrol 1991
:
The
effects of
endothelin on fluid and bicarbonate absorption and Na+/K+
ATPase activity in the proximal straight tubule were investigated
Meyer-Lehnert et al., Biochem Biophys Res Commun 1989
:
Therefore, we examined the
effects of
endothelin on
Na-K-ATPase in an enzyme preparation from hog cerebral cortex ... At high concentrations,
endothelin ( 10 ( -5 ) M )
inhibited Na-K-ATPase in vitro