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SOX4 — TCF23
Text-mined interactions from Literome
Passeron et al., Proc Natl Acad Sci U S A 2007
:
During melanocyte development from the neural crest,
SOX10 regulates microphthalmia associated
transcription factor , which controls a set of genes critical for pigment cell development and pigmentation, including dopachrome tautomerase and tyrosinase ... In adult and neonatal melanocytes,
SOX9 regulates microphthalmia associated
transcription factor , dopachrome tautomerase, and tyrosinase promoters, leading to an increase in the expression of these key melanogenic proteins and finally to a stimulation of pigmentation
Sinner et al., Mol Cell Biol 2007
(Carcinoma...) :
Sox17 and Sox4 are expressed in mutually exclusive domains in normal and neoplastic gut tissues, and gain- and loss-of-function studies demonstrate that
Sox4 enhances
beta-catenin/TCF activity and the proliferation of SW480 cells
Chen et al., Liver Int 2013
(Carcinoma, Hepatocellular...) :
In addition,
SOX4 in HepG2 cell can
enhance ß-catenin/TCF activity by increasing ß-catenin level