Gene interactions and pathways from curated databases and text-mining

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CLDN4 — EPHB2

Text-mined interactions from Literome

Cohen et al., PloS one 2010 (MAP Kinase Signaling System...) : Expression of claudin 4 , claudin 18, and occludin was significantly lower, and activation of JNK and ERK signaling pathways was significantly increased in 2CLP monolayers, relative to sham monolayers ... Inhibition of ERK , not JNK, significantly increased TER and expression of claudin 4 in 2CLP monolayers, and prevented significant differences in claudin 18 expression between 2CLP and sham monolayers
Okumura et al., J Gastroenterol 2010 (Gastrointestinal Neoplasms...) : Inhibition of MEK-ERK signaling mediated up-regulation of E-cadherin and claudin-4 , and/or decreased expression of matrix metalloproteinases ( MMPs ) such as MMP-2 and MMP-9, play a role in the TZD induced inhibition of cancer cell invasion