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CRH — EPHB2

Text-mined interactions from Literome

Dermitzaki et al., J Biol Chem 2002 : CRH also promoted a rapid and transient activation of ERK1/2 , which, however, was not necessary for either CRH induced apoptosis or Fas ligand production
Kovalovsky et al., Mol Endocrinol 2002 (MAP Kinase Signaling System) : CRH/cAMP stimulated ERK2 activity and increased transcriptional activity of a Gal4-Elk1 protein, which was blocked by overexpression of dominant negative mutants and kinase inhibitors and stimulated by expression of B-Raf
Brar et al., Endocrinology 2004 : CRF and Ucn-I but not Ucn-II or Ucn-III activates ERK1/2-p42 , 44 in Chinese hamster ovary cells stably expressing CRFR1
Refojo et al., Proc Natl Acad Sci U S A 2005 : Other regions such as hypothalamic nuclei and the central nucleus of the amygdala, also related to central CRH system but involved in the processing of the ascending visceral information and neuroendocrine-autonomic response to stress, did not show CRH mediated ERK1/2 activation ... These findings underscore the fact that CRH activates p-ERK1/2 through CRHR1 only in selected brain regions, pointing to a specific role of this pathway in mediating behavioral adaptation to stress
Cao et al., Mol Pharmacol 2006 : CRH did not stimulate ERK or JNK phosphorylation and did not increase intracellular calcium levels
Traver et al., Mol Pharmacol 2006 : However, downstream of ERK1/2 activation by CRF , the phenotypic induction of noradrenergic neurons relied upon the stimulation of the phosphatidylinositol-3-kinase/Akt transduction pathway by BDNF
Kageyama et al., Mol Cell Endocrinol 2007 : CRF increased ERK phosphorylation in AtT-20 cells, whereas the UCNs decreased it in A7r5 cells
Yang et al., Exp Dermatol 2007 (Melanoma...) : Furthermore, CRH induced the phosphorylation of ERK1/2 ... The maximum activation of ERK1/2 by CRH was observed at 15 min. Taken together, these results suggest that CRH is an important mediator that regulates the migration of melanoma cells in the skin during stress through the ERK1/2 signaling pathway
Wu et al., Endocrinology 2007 : The expression of CRF2 receptor protein and intracellular cAMP and ERK1/2 responses to CRF agonists and CRF2 antagonist were determined in cultured esophageal cells and HEK-293 cells transfected with CRF2b receptors
Wang et al., Placenta 2007 : Stimulation of the cells with CRH caused a rapid and transient phosphorylation of p38/MAPK while CRH had no effect on ERK1/2 activation
Silberstein et al., Neuroscience 2009 (Disease Models, Animal) : In the present study, we used CRH-COE-Cam mice that overexpress CRH in limbic restricted areas, to analyze the effect of chronic CRH overexpression on ERK1/2 activation ... Chronic CRH overexpression leads to reduced ERK1/2 activation in response to acute stress in the BLA
Van Kolen et al., Neuropharmacology 2010 : Corticotropin releasing factor induced ERK phosphorylation in AtT20 cells occurs via a cAMP dependent mechanism requiring EPAC2 ... CRF induced ERK phosphorylation has been shown to be an important mechanism underlying expression of pro-opiomelanocortin, a key precursor molecule in the hypothalamic pituitary adrenal axis ... In AtT20 cells, CRF signalling has been investigated but the mechanism behind CRF induced ERK activity is not fully understood ... Treatment with PKA inhibitors had a minor effect on CRF induced ERK signalling while phosphorylation of CREB was completely abolished ... Moreover, an activator of EPACs 8- ( 4-methoxyphenylthio ) -2'-O-methyladenosine-3',5'-cyclic monophosphate mimicked CRF induced ERK phosphorylation ... The current study demonstrates a clear cAMP dependent but PKA independent mechanism underlying CRF induced ERK activity that proceeds via EPAC2 signalling
Wu et al., Endocrinology 2011 : CRH and Ucn-1, but not Ucn-2, stimulated significant ERK1/2 phosphorylation
Bonfiglio et al., Mol Endocrinol 2013 : B-Raf and CRHR1 Internalization Mediate Biphasic ERK1/2 Activation by CRH in Hippocampal HT22 Cells ... In a previous work, we demonstrated that CRH activates ERK1/2 in limbic areas of the mouse brain ( hippocampus and basolateral amygdala ) ... To elucidate the molecular mechanisms by which CRH activates ERK1/2 in hippocampal neurons, we used the mouse hippocampal cell line HT22 ... We document for the first time that ERK1/2 activation in response to CRH is biphasic, involving a first cAMP- and B-Raf dependent early phase and a second phase that critically depends on CRHR1 internalization and ß-arrestin2 ... Using molecular and pharmacological tools, the functional impact of selected B-Raf partners in CRH dependent ERK1/2 activation was dissected ... These results indicate that 14-3-3 proteins, protein kinase A, and Rap1, are essential for early CRH induced ERK1/2 activation, whereas dynamin and vimentin are required for the CRHR1 internalization dependent phase