Gene interactions and pathways from curated databases and text-mining

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EPHB2 — NCF1

Text-mined interactions from Literome

Dewas et al., J Immunol 2000 : Inhibition of ERK1/2 activation by PD98059, a specific inhibitor of ERK kinase 1/2, inhibited the fMLP induced phosphorylation of p47(phox) ... Two-dimensional phosphopeptide mapping analysis showed that, in fMLP induced p47(phox) phosphorylation, PD98059 affected the phosphorylation of all the major phosphopeptides, suggesting that ERK1/2 may regulate p47(phox) phosphorylation either directly or indirectly via other kinases
Yamakawa et al., Arterioscler Thromb Vasc Biol 2002 (MAP Kinase Signaling System) : The overexpression of dominant negative p47phox in A10 cells suppressed lysoPC induced ERK activation
Chen et al., Am J Physiol Heart Circ Physiol 2007 (Anoxia...) : Our findings underscore the important role of NADPH oxidase and its subunit p47(phox) in modulating Akt and ERK1/2 activation, angiogenic growth factor expression, and angiogenesis in myocardium undergoing I/R
Tsai et al., Eur J Pharmacol 2013 (MAP Kinase Signaling System) : Taken together, these results suggest that the ERK mediated Ser phosphorylation of p47(phox) is not implicated in the assembly of NADPH oxidase or O2 ( - ) generation, and that O2 ( - ) generation is partly attributable to p38 MAPK signaling through mechanisms other than p47(phox) activation, Akt activation and S100A9 membrane recruitment in fMLP stimulated neutrophils