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P2RX7 — P2RY2
Text-mined interactions from Literome
D'Alimonte et al., Int J Immunopathol Pharmacol 2007
:
To further investigate the mechanisms by which
P2X(7) receptors
mediated the
P2Y(2) mRNA up-regulation, the cells were pre treated with the chelating agent EGTA, or with inhibitors of mitogen activated kinase ( MAPK ) ( PD98059 ) or protein kinase C, ( GF109203X ) ... We conclude that activation of
P2X(7) receptors in astrocytes
enhances P2Y(2) mRNA expression by a mechanism involving both calcium influx and PKC/MAPK signalling pathways
Mishra et al., J Cell Sci 2011
:
These results suggest that the activation of
P2X(7)R increases surfactant secretion by releasing ATP from AEC I and subsequently
stimulating P2Y(2) receptors in AEC II