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HSPD1 — IGF1R
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Shan et al., J Biol Chem 2003
(Diabetes Mellitus, Experimental) :
Hsp10 and
Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and
augment insulin-like growth factor-1 receptor signaling in cardiac muscle : implications on decreased myocardial protection in diabetic cardiomyopathy ... Compared with the cells transduced with a control vector, overexpression of Hsp10 or
Hsp60 increased the abundance of
IGF-1R and IGF-1 stimulated receptor autophosphorylation ... Thus, Hsp10 and
Hsp60 overexpression
increased the number of functioning receptors and amplified activation of
IGF-1R signaling ... Using cycloheximide to inhibit protein synthesis did not alter the effect of Hsp60 on
IGF-1R signaling, and IGF-1R mRNA levels were not
up-regulated by Hsp10 or
Hsp60
Lai et al., Am J Physiol Endocrinol Metab 2007
(Diabetes Mellitus, Experimental) :
In the mitochondria depleted cells, overexpression of
HSP60 with adenoviral vector
increased the abundance of
IGF-I receptor , enhanced IGF-I activated receptor phosphorylation, and augmented IGF-I activation of Akt and ERK ... Thus overexpressing
HSP60 in the cytosolic compartment
enhanced IGF-I receptor signaling through upregulation of IGF-I receptor protein