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APOB — ATP5O
Text-mined interactions from Literome
Rabini et al., J Clin Endocrinol Metab 1999
(Diabetes Mellitus, Type 1) :
IDDM
LDL significantly increased the platelet aggregating response to ADP, cytosolic Ca2+ concentrations, and plasma membrane Ca2+-ATPase activity and significantly
reduced NOS activity and platelet membrane
Na+/K+-ATPase activity compared with those of platelets incubated in buffer or cells incubated with control LDL
Zabe et al., Cell Calcium 1999
:
We have previously demonstrated that Cu ( 2+ ) -oxidized
LDL inhibits platelet plasma membrane Ca ( 2+ )
-ATPase ( PMCA ) in isolated membranes and causes an increase in cytosolic Ca2+ in resting whole platelets
Sakr et al., J Biol Chem 2001
:
Degradation of matrix retained, but not soluble,
LDL was also
blocked by inhibitors of tyrosine kinase, phosphatidylinositol 3-kinase, and myosin
ATPase
Usuki et al., Nutrition & metabolism 2007
:
The inhibitory
effect of HT-modified
LDL on
Na+/K+-ATPase activity disappeared when TLp was added to the incubation mixture
Kumar et al., Indian J Pharmacol 2012
(Disease Models, Animal...) :
Further, mean arterial blood pressure, heart rate, serum leptin, insulin, LDH, LDL-C, total cholesterol, triglycerides, and
apolipoprotein-B levels were
enhanced significantly, whereas serum HDL-C, apoliporotein-A1 levels, and cardiac Na ( + ) K ( + )
ATPase , antioxidant enzymes levels were significantly decreased
Zhao et al., Cell Calcium 1996
:
Since platelet activation is accompanied by an increase in cytosolic calcium, the
effects of oxidized
LDL on plasma membrane Ca ( 2+ )
-ATPase , plasma membrane fluidity and cytoplasmic calcium were studied in human platelets and purified platelet plasma membranes ... Our results demonstrate that oxidized
LDL , but not native LDL,
inhibits the activity of Ca ( 2+ )
-ATPase in purified platelet plasma membranes ( P < 0.01 ) ... Addition of the free radical scavenger alpha-tocopherol had no effect on the ability of oxidized
LDL to
inhibit the Ca ( 2+ )
-ATPase ... Since no change in membrane fluidity was observed in platelet plasma membranes exposed to oxidized or native LDL as estimated by steady state trimethylammonium diphenylhexatriene ( TMA-DPH ) anisotropy, oxidized
LDL does not
affect the Ca ( 2+ )
-ATPase by grossly changing the membrane environment