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FGF19 — FXR1

Text-mined interactions from Literome

Holt et al., Genes Dev 2003 : We demonstrate that FXR directly regulates expression of fibroblast growth factor-19 (FGF-19) , a secreted growth factor that signals through the FGFR4 cell-surface receptor tyrosine kinase
Inagaki et al., Cell Metab 2005 : FGF15 expression is stimulated in the small intestine by the nuclear bile acid receptor FXR and represses Cyp7a1 in liver through a mechanism that involves FGF receptor 4 (FGFR4) and the orphan nuclear receptor SHP
Gutierrez et al., Arterioscler Thromb Vasc Biol 2006 (Atherosclerosis...) : Hepatic PON1 and CYP7A1 mRNA expression is repressed by bile acids via FXR mediated induction of FGF15
Shin et al., J Biol Chem 2009 : The bile acid receptor FXR ( farnesoid X receptor ) activates expression of fibroblast growth factor ( FGF ) 15 in the intestine, which acts through hepatic FGFR4 to suppress cholesterol-7alpha hydroxylase ( CYP7A1 ) and limit bile acid production
Mencarelli et al., J Cell Mol Med 2010 (Atherosclerosis) : In the intestine FXR induces the release of fibroblast growth factor 15 ( FGF15 ) ( or FGF19 in human ), which activates hepatic FGF receptor 4 (FGFR4) signalling to inhibit bile acid synthesis
Zhang et al., PloS one 2011 : Both resin fed and FXR-null mouse models indicate that BAs regulate their own biosynthesis through the FXR regulated ileal fibroblast growth factor 15
Matysik et al., Chem Phys Lipids 2011 : The efficacy of the different pathways to regulate bile acid synthesis through short heterodimer partner ( SHP ) dependent FXR modulation in liver, and SHP independent activation via FGF19 is demonstrated
Zweers et al., Hepatology 2012 : In the postprandial state, activation of ileal farnesoid X receptor ( FXR ) by bile salts results in transcriptional induction of FGF19 and elevation of circulating FGF19 levels
Kong et al., Hepatology 2012 : FXR mediated induction of hepatic small heterodimer partner ( SHP/Shp, Nr0b2 ) and intestinal fibroblast growth factor 15 ( Fgf15 ; FGF19 in humans ) has been shown to be responsible for this suppression
Burrin et al., J Anim Sci 2013 : A dominant effect of intestinal FXR activation by bile acids is secretion of fibroblast growth factor (FGF) 19 , a novel enterokine that functions as a central enterohepatic signal to maintain bile acid homeostasis in the liver
Seok et al., J Biol Chem 2013 : BAs activate multiple signaling pathways, including those of nuclear receptors, primarily farnesoid X receptor ( FXR ), membrane BA receptors, and FXR induced FGF19 to regulate the fed-state metabolism