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HRAS — VEGFA
Text-mined interactions from Literome
Casanova et al., Cancer Res 2002
(Cell Transformation, Neoplastic...) :
This study reports that activated Ha-ras results in a dramatic induction of EGFR in epidermal tumor cells and provides experimental evidence that EGFR signaling is responsible for
Ha-ras dependent
vascular endothelial growth factor ( VEGF ) induction, as well as for the repression of other angiogenic factors such as angiopoietin 1
Shu et al., Mol Cell Biol 2002
(Carcinoma...) :
VEGF stimulation of T24 cells
caused a slow and sustained accumulation of
Ras-GTP and phosphorylated extracellular signal regulated kinase ( phospho-ERK ) compared with that after EGF treatment ... Small interfering RNA ( siRNA ) that targets SPK1, but not SPK2, blocks
VEGF induced
accumulation of
Ras-GTP and phospho-ERK in T24 cells
Basu et al., PloS one 2011
(Kidney Neoplasms) :
The overexpression of PRAS40 in renal cancer cells significantly down-regulated CNI- and
H-Ras induced
VEGF transcriptional activation
Grugel et al., J Biol Chem 1995
(Cell Transformation, Neoplastic) :
Both
v-Ha-Ras and v-Raf
stimulate expression of the
vascular endothelial growth factor in NIH 3T3 cells
Larcher et al., Cancer Res 1996
(Carcinoma, Squamous Cell...) :
Up-regulation of
vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and
activated H-ras expression levels