Yang et al., Virology 2002
:
DNA binding and functional assays examined the role played by NF-IL6 in regulation of HIV-1 transcription in human monocyte/macrophages ( U937 cells ), stimulated with LPS+PMA ... In functional assays, increasing concentrations of a decoy against NF-IL6 reduced gene expression from the LTR of the wild-type HIV-1 variant, supporting a critical role for NF-IL6 in regulation of HIV-1 transcription in stimulated monocyte/macrophages ... The results implied that in LPS+PMA stimulated monocyte/macrophages, the endogenous NF-IL6 could act via a site independent pathway in upregulation of HIV-1 transcription Buckner et al., Virus Res 2002
:
Regulation of HIV-1 transcription by NF-IL6 in activated Jurkat T cells
Asin et al., J Infect Dis 2009
(HIV Infections) :
Our results suggest that the ectocervix is more conducive to HIV-1 replication than is the endometrium and that IL-6 enhances HIV-1 transcription at this site