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CRP — IL8

Text-mined interactions from Literome

Devaraj et al., J Mol Cell Cardiol 2004 (Arteriosclerosis) : In conclusion, this study makes the novel observation that CRP induces IL-8 synthesis and secretion in HAEC via upregulation of NF-kappa B activity
Rodríguez et al., Clin Exp Immunol 2004 : We examined responses reported to be dependent on FcgammaRIIa but no difference between groups was observed in CRP mediated phagocytosis of S. pneumoniae, reactive oxygen production, or IL-8 synthesis
Ivashchenko et al., Arterioscler Thromb Vasc Biol 2005 (Carcinoma, Hepatocellular...) : Importantly, IL-8 significantly induced CRP release in PHHs by 58.675+/-19.1-fold, which was blockable by LY333531
Wang et al., Am J Physiol Heart Circ Physiol 2005 (MAP Kinase Signaling System) : Inhibition of ERK MAPK pathway using U0126 prevented CRP induced IL-8 upregulation, and Western blot analysis revealed a rapid activation of ERK1/2 after CRP stimulation
Kibayashi et al., Clin Sci (Lond) 2005 (Arteriosclerosis) : Inhibitory effect of pitavastatin ( NK-104 ) on the C-reactive-protein induced interleukin-8 production in human aortic endothelial cells ... We also investigated whether CRP can induce IL-8 production and if the activation of signalling pathways are functionally related ... The production of IL-8 induced by CRP ( 10 microg/ml ) was enhanced significantly and was inhibited by pitavastatin
Szmitko et al., Clin Sci (Lond) 2005 (Inflammation) : Kibayashi and co-workers in this issue of Clinical Science confirm that CRP induces IL-8 production in human aortic endothelial cells in vitro, via the activation of MAPKs ( mitogen activated protein kinases ), an effect that can be inhibited by pitavastatin
Xie et al., J Cardiovasc Pharmacol 2005 : C-reactive protein augments interleukin-8 secretion in human peripheral blood monocytes ... We assessed whether C-reactive protein could induce MCP-1 and IL-8 secretion ... In human peripheral blood monocytes, C-reactive protein ( 12.5-50 microg/mL ) increased IL-8 , but not MCP-1 secretion in a time- ( 6-24 hours ) and dose dependent manner as detected by ELISA ... C-reactive protein could augment the production of reactive oxygen species ( ROS ) as measured by chemiluminescence and inhibitors of NAD ( P ) H oxidase ( DPI and PAO ) and ROS scavengers ( superoxide dismutase, catalase, and 1 % dimethyl sulphoxide ) abolished C-reactive protein induced IL-8 secretion ... The inhibitors of ERK 1/2 ( PD98059 ), p38 ( SB203580 ) MAPK, and NF-kappaB ( PDTC and MG132 ) significantly decreased C-reactive protein induced IL-8 secretion in human monocytes ... Thus, our data indicate that C-reactive protein at pathologic levels increases IL-8 secretion and mRNA via enhancing ROS derived mainly from NAD ( P ) H oxidase and the subsequent activation of ERK1/2, p38 MAPK, and NF-kappaB ... The activation of PPARalpha/gamma can negatively regulate C-reactive protein induced IL-8 production in human monocytes
Haider et al., Clin Exp Immunol 2006 (Endotoxemia) : LPS, interleukin (IL)-1 , IL-6 and tumour necrosis factor (TNF)-alpha increased and IL-10 reduced CRP expression in PBMC
Peroś-Golubicić et al., Acta Med Iugosl 1991 (Lung Diseases...) : It is well known that interleukin-1 , among other functions, stimulates the hepatic production of C-reactive protein
Nan et al., Chin Med J (Engl) 2009 : We, herein, investigated the direct effect of CRP on IL-8 production and gene expression in cultured human EPCs ... The results showed that CRP at a concentration of 10 microg/ml significantly reduced IL-8 secretion of cultured EPCs with a peak at 25 microg/ml, and also decreased mRNA expression in EPCs with a peak at 12 hours ... In addition, preincubation of EPCs with SB203580, an inhibitor of p38 mitogen activated protein kinase ( MAPK ) decreased CRP inhibition of IL-8 mRNA expression at 12 hours in EPCs ... Our study, for the first time, demonstrates that CRP directly inhibits EPCs IL-8 secretion, a key cytokine player of angiogenesis induced by EPCs ... The ability of CRP to inhibit EPCs IL-8 secretion may represent an important mechanism that further links inflammation to cardiovascular disease
Lands et al., J Med Food 2010 (Cystic Fibrosis...) : Anthropometric measures, pulmonary function, serum C-reactive protein (CRP) , whole blood glutathione, and whole blood IL-8 and IL-6 responses to phytohemagglutinin ( PHA ) stimulation were measured at baseline and at 1 month
Wang et al., Exp Eye Res 2010 : In the presence of inhibitors for NF-kB, p38, MEK and JNK, the CRP induced IL-8 production was abolished by 99.5+/-2.3, 97.8+/-2.1, 55.3+/-2.5 and 37.3+/-1.3 %, respectively
Mackiewicz et al., Biochem J 1988 : While both interleukin-1 and tumour necrosis factor regulate biosynthesis of a number of these acute phase proteins in rabbit primary hepatocyte cultures, neither of these monokines induced C-reactive protein synthesis
Zhang et al., Biochem J 1995 : The effect of interleukin-1 on C-reactive protein expression in Hep3B cells is exerted at the transcriptional level