Gene interactions and pathways from curated databases and text-mining

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ITGB1 — MMP9

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

DiPersio et al., J Cell Sci 2000 : Mouse keratinocytes immortalized with large T antigen acquire alpha3beta1 integrin dependent secretion of MMP-9/gelatinase B
Redondo-Muñoz et al., Blood 2006 (Leukemia, B-Cell...) : MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration
Talamagas et al., Neurobiol Dis 2007 : Up-regulation of MMP-9 expressed by SK-N-SH cells in the presence of Abeta ( 1-40 ) was mediated by alpha ( 3 ) beta ( 1 ) and alpha(2)beta(1) integrin receptors
Das et al., Life Sci 2008 (Breast Neoplasms) : Blocking of alpha5beta 1 integrin with anti-alpha5 monoclonal antibody inhibits the fibronectin induced MMP activation response appreciably
Bezuidenhout et al., Inflammation 2009 : Additionally, integrin beta(2) blockade significantly inhibited the Ang-2/PDGF-BB based increase in matrix metalloproteinase-9 (MMP-9) and membrane type-1-MMP (MT1-MMP)
Huhtala et al., J Cell Biol 1995 : In contrast, peptide V from the heparin binding region, shown previously to stimulate focal contact formation, further enhanced MMP expression by RSF when present on the substrate with 120FN. RSF expressed alpha 4 beta 1 integrin , the receptor for CS-1, and the anti-alpha 4 mAb blocked the ability of CS-1 to suppress MMP induction by 120FN