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ADCYAP1 — BCL2

Text-mined interactions from Literome

Falluel-Morel et al., J Neurochem 2004 : C2-ceramide stimulated Bax expression, but had no effect on Bcl-2, while PACAP abrogated the action of C2-ceramide on Bax and stimulated Bcl-2 expression ... The effects of C2-ceramide and PACAP on Bax and Bcl-2 were blocked, respectively, by the JNK inhibitor L-JNKI1 and the MEK inhibitor U0126 ... U0126 blocked PACAP induced Bcl-2 expression, abrogated the inhibitory effect of PACAP on ceramide induced caspase-9 activity, and promoted granule cell death
Rácz et al., Regul Pept 2008 (Myocardial Reperfusion Injury) : Furthermore, PACAP increased the levels of Bcl-xL and 14-3-3 protein, both of which promote cell survival, and decreased the apoptosis executor caspase-3 cleavage
Sanchez et al., Regul Pept 2009 : However, the decrease in Bcl-2 evoked by thrombin is not affected by PACAP38
Horvath et al., J Mol Neurosci 2010 (Reperfusion Injury) : Therefore, the aim of the present study was to obtain further insight into the renoprotective effects of PACAP by examining its direct effects of PACAP on mitochondrial permeability transition in vitro and on the expression of the anti-apoptotic Bcl-2 and cytokines/chemokines in kidney tissues following 45 and 60 min renal ischemia and reperfusion in vivo