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AGTR1 — VEGFA

Text-mined interactions from Literome

Fujiyama et al., Circ Res 2001 : Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF) mediated EGF receptor transactivation ... In an in vivo corneal assay, AT(1) induced angiogenesis in an HB-EGF dependent manner and enhanced the angiogenic activity of VEGF
Yamagishi et al., Drugs Exp Clin Res 2003 : Angiotensin II-type 1 receptor interaction upregulates vascular endothelial growth factor messenger RNA levels in retinal pericytes through intracellular reactive oxygen species generation
Rizkalla et al., J Am Soc Nephrol 2003 : Increased renal vascular endothelial growth factor and angiopoietins by angiotensin II infusion is mediated by both AT1 and AT2 receptors
Kikkawa et al., Am J Obstet Gynecol 2004 (Carcinoma, Squamous Cell...) : Angiotensin II is involved in the progression of cervical carcinoma, because it induces the secretion of vascular endothelial growth factor through angiotensin II type I receptor , which results in the increased invasiveness of carcinoma cells
Fujita et al., Carcinogenesis 2005 (Neovascularization, Pathologic...) : These suggest that host stromal VEGF induction by AT1a-R signaling is a key regulator of tumor associated angiogenesis and tumor growth
Kang et al., J Mol Endocrinol 2006 (MAP Kinase Signaling System) : Prior treatment with losartan significantly inhibited VEGF mRNA and protein synthesis induced by Ang-II, which suggests that the AT1 receptor is involved in Ang-II mediated VEGF synthesis
Kitayama et al., Am J Hypertens 2006 (Disease Models, Animal...) : These results demonstrate that an infusion of ang II induced the expression of VEGF mainly through AT1 receptors, and increased the expression of VEGF receptors, tie-2, and Ang1/Ang2 ratio mainly through AT2 receptors
Kosaka et al., Prostate 2007 (Prostatic Neoplasms) : We previously demonstrated that specific AT1R blockade with candesartan, an AT1R antagonist, inhibited vascular endothelial growth factor ( VEGF ) production and dramatically decreased lung metastasis of renal cancer by inhibiting tumor angiogenesis
Imai et al., Lab Invest 2007 (Carcinoma, Lewis Lung...) : VEGFa induction by AT1 receptor signaling in both host and tumor tissues is one of key regulators of tumor growth and tumor associated angiogenesis
Anandanadesan et al., J Gastrointest Surg 2008 (Carcinoma, Pancreatic Ductal...) : Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1/2 signaling ... VEGF followed the same distribution pattern of AT1R in both lesions ... An AT1R mediated VEGF induction suggests the possibility of AT1R blockade as a novel therapeutic strategy to control angiogenesis in PDA
Ishida et al., Nihon Ganka Gakkai Zasshi 2009 (Diabetic Retinopathy...) : We have found that tissue RAS is activated in the pathogenesis of diabetic retinopathy and CNV, leading to angiotensin type 1 receptor(AT1-R) mediated expression of inflammation related molecules including vascular endothelial growth factor ( VEGF ), intercellular adhesion molecule (ICAM)-1, and monocyte chemotactic protein(MCP)-1
Day et al., Cell Signal 2010 (Hyperglycemia) : Blockade of AT2, but not AT1 , prevented increase in VEGF synthesis by inhibiting translation of VEGF mRNA in renal cortex
Akhavan et al., Pak J Biol Sci 2011 (Melanoma) : AT1 receptors activation enhances the expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 melanoma cells