Gene interactions and pathways from curated databases and text-mining

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ANXA6 — PTBP2

Text-mined interactions from Literome

Mosca et al., Blood 2000 : Phenotypically mature DCs could be induced to produce high levels of IL-12 p70 only when provided 2 simultaneous stimulatory signals
Kandil et al., Clin Exp Immunol 2005 (Necrosis) : Furthermore, priming DCs with necrotic cells augmented IL-12p70 secretion significantly in conjunction with CD40 cross linking
Jongmans et al., J Immunother 2005 (Inflammation) : No IL-12p70 could be detected when DCs were stimulated with TNF-alpha/PGE2 combined with MCM or IL-1beta/IL-6, presumably by suppression by PGE2
Tada et al., Infect Immun 2005 : The stimulation of DCs with MDP and FK565 in combination with lipid A, poly ( I:C ), and CpG DNA, but not with Pam3CSSNA, synergistically induced interleukin-12 (IL-12) p70 and gamma interferon ( IFN-gamma ), but not IL-18, in culture supernatants and induced IL-15 on the cell surface
Trepiakas et al., Vaccine 2008 (Neoplasms) : This DC maturation cocktail was described to fulfill the criteria for optimal DC generation and to be superior to the standard DC ( sDC ) cocktail as it induced fully mature DCs with potent IL-12p70 secretion together with CCR7 expression which is necessary for priming of a TH1 response and for migration to the draining lymph node, respectively
Liu et al., Zhonghua Er Ke Za Zhi 2008 : ( 1 ) By up-regulating splenic CD8alpha ( + ) DCs and inducing IL-12p70 and IL-10 production in BALB/c mice, neonatal BCG vaccination promoted Th1/Tr1 development
Charoensap et al., Trans R Soc Trop Med Hyg 2008 (Melioidosis) : We also found that, although the LPS mutant could readily activate monocyte derived human DCs , it induced lower levels of IL-12p70 and IL-10 production than its wild-type counterpart ( P < 0.01 )
Ceballos et al., J Exp Med 2009 : Interaction of spermatozoa with DCs not only leads to the transmission of HIV-1 and the internalization of the spermatozoa but also results in the phenotypic maturation of DCs and the production of IL-10 but not IL-12p70
Marin-Esteban et al., J Immunother 2010 (Neoplasms) : LPS stimulation of DCs induced IL-10, IL-12p70 , TNFalpha and IL-1beta secretion, and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion
Kubota et al., Scand J Immunol 2010 (Staphylococcal Infections) : However, a number of reports have shown that bacterial stimuli are unable to induce macrophages and/or DCs to produce sufficient amounts of IL-12p70 unless these cells are primed by IFN-gamma
Kono et al., Vaccine 2012 (Listeriosis) : However, it has been reported that standard fully mature DCs show reduced ability to produce IL-12p70 upon subsequent interaction with antigen ( Ag ) -specific T cells, limiting their in vivo performance for vaccines
Lewkowich et al., Mucosal Immunol 2013 : Decreased AHR was associated with enhanced serum interleukin (IL)-12 p40, and in vitro stimulation of DCs with allergen and PD-L2-Fc reduced IL-12 p70 production, suggesting that PD-L2 inhibits allergen-driven IL-12 production