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EGR1 — PDGFA

Text-mined interactions from Literome

Day et al., J Biol Chem 1999 : Angiotensin II ( ATII ) -inducible platelet derived growth factor A-chain gene expression is p42/44 extracellular signal regulated kinase-1/2 and Egr-1 dependent and mediated via the ATII type 1 but not type 2 receptor
Houston et al., Biochem Biophys Res Commun 2001 : NAB2 blocks Egr-1 activation of the tissue factor ( TF ) promoter, Egr-1 stimulated production of PDGF-AB , HGF, TGFbeta(1), and VEGF and the endogenous expression of PDGF-AB and TGFbeta(1)
Worden et al., Cancer Res 2005 (Carcinoma, Squamous Cell...) : Consistent with this, expression of PDGFA and VEGF but not IL-8 showed corresponding differences with Egr-1 expression in HNSCC tumor specimens and were strongly suppressed by transfection of Egr-1-antisense or small interference RNA ( siRNA ) oligonucleotides
Khachigian et al., J Biol Chem 1995 : PMA induces Egr-1 mRNA expression within 1 h, whereas PDGF-A transcript levels increase after 2-4 h. Constitutive levels of Sp1 are not altered over 24 h
Delbridge et al., Circ Res 1997 : These findings indicate that Egr-1 plays a key regulatory role in FGF-1-inducible endothelial PDGF-A expression and implicate this transcription factor in pathological settings in which these mitogens are both expressed
Silverman et al., Am J Physiol 1997 : In an in vivo model of arterial injury, Egr-1 expression was induced concurrently with the expression of PDGF-A in SMC