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EGR1 — PLG

Text-mined interactions from Literome

De Sousa et al., Biochem Biophys Res Commun 2005 (MAP Kinase Signaling System) : Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathway ... Leupeptin, a serine protease inhibitor, suppressed Pla but not Plg induced c-fos and egr-1 expression, emphasizing the role played by the serine protease activity associated with Pla ... Furthermore, Plg/Pla also stimulated AP-1 and EGR-1 DNA binding activities, which were abrogated by pharmacological inhibition of MEK ... Altogether, these results suggest that Plg/Pla stimulates c-fos and egr-1 expression via activation of the MEK/ERK pathway
Sousa et al., Biochem Biophys Res Commun 2005 (MAP Kinase Signaling System) : Previously we have demonstrated that both plasminogen (Plg) and plasmin (Pla) regulate the expression of the transcription factors c-FOS and EGR-1 [ L.P. De Sousa, B.S. Brasil, B.M. Silva, M.H. Freitas, S.V. Nogueira, P.C. Ferreira, E.G. Kroon, C.A. Bonjardim, Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathway, Biochem
Yoshida et al., Blood Coagul Fibrinolysis 2007 (Carcinoma, Small Cell...) : Urokinase-type plasminogen activator and interleukin-8 are important biological factors in tumor cell regulation ; STI571 may therefore influence many aspects of tumor cell biology through inducing urokinase-type plasminogen activator and interleukin-8, in which the induction of early growth response-1 expression and extracellular signal regulated kinase 1/2 phosphorylation might be involved
Matsunoshita et al., PloS one 2011 (Neoplasm Invasiveness...) : In addition, forced expression of EGR1 promoted down-regulation of urokinase plasminogen activator, urokinase receptor, and urokinase plasminogen activity