Liao et al., BMC developmental biology 2009
(Anoxia) :
We examined expression of CAIX, CAXII and HIF-1alpha in the developing human fetus and postnatal tissues to determine whether expression of CAIX and CAXII is exclusively regulated by HIF-1 Chiche et al., Ann Endocrinol (Paris) 2013
:
We reported that targeting these pHi regulated processes through inhibition of either HIF-1 induced CAIX/CAXII or HIF-1 induced MCT4, MCT1 or Basigin/EMMPRIN/CD147 chaperone of MCTs, severely restricts glycolysis generated ATP levels and tumor growth