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CASP4 — VEGFA
Text-mined interactions from Literome
Jin et al., Neuroscience 2001
(Hypoxia, Brain...) :
VEGF inhibited the activation of
caspase-3 as measured by the 17-20-kDa caspase-3 cleavage product, and immunolocalization of VEGF and activated caspase-3 showed segregated expression in separate neuronal populations
Kaneko et al., J Cell Sci 2004
:
Furthermore, transfection of antisense ILK ( ILK-AS ) blocked the survival effect of VEGF in annexin-V binding assays, and a
VEGF mediated decrease in
caspase activity was reversed by both ILK-KD and ILK-AS as measured by a homogeneous caspase-3/7 assay
Lee et al., Blood 2004
(Leukemia, Lymphocytic, Chronic, B-Cell) :
Thus, these results suggest that
VEGF signaling regulates survival signals in CLL cells and that interruption of this autocrine pathway
results in
caspase activation and subsequent leukemic cell death
Wang et al., Brain 2005
(Brain Ischemia...) :
Following transient intraluminal middle cerebral artery ( MCA ) occlusions,
VEGF overexpression significantly alleviated neurological deficits and infarct volume, and
reduced disseminated neuronal injury and
caspase-3 activity, confirming earlier observations that VEGF has neuroprotective properties
Addison et al., BMC cell biology 2005
:
Further analysis determined that endostatin did not decrease the expression of bcl-2 nor did it increase activation of
caspase-3 in the
presence of
VEGF ... Alternatively, it appeared that in the
presence of
VEGF , endostatin induced the activation of
caspase-8 in endothelial cells grown on collagen I
Zhu et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005
:
To explore the effects of vascular endothelial growth factor ( VEGF ) on the mechanisms of CML pathogenesis, the effect of VEGF on K562 cell apoptosis induced by As ( 2 ) O ( 3 ) was analyzed through morphologic observation, DNA fragmentation agarose gel electrophoresis and DNA ploidy flow cytometry analysis, and the
effect of
VEGF on the expression of bcl-X ( L ), Bax and
caspase-3 in K562 cells was determined by Western blot, meanwhile the expression difference between bcl-X ( L ) and Bax mRNA in above conditions was detected by RT-PCR
Berger et al., Journal of negative results in biomedicine 2006
:
While no functional effects of VEGF on PC12 cell proliferation and differentiation could be observed, a slight
VEGF induced reduction of
caspase-3 activity in differentiated apoptotic PC12 cells was paralleled by transient activation of ERK1/2 and Akt
Yang et al., Neurosci Lett 2008
(Brain Ischemia...) :
NGF/VEGF significantly
inhibited the expression of ERK1 and
caspase-3
Yang et al., J Invest Surg 2009
(Infarction, Middle Cerebral Artery...) :
VEGF inhibited the cell apoptosis and the expressions of caspase-12 and
caspase-3
Abramovich et al., Fertil Steril 2010
:
Inhibition of
VEGFA leads to a decrease in the expression of the proliferation marker proliferating cell nuclear antigen ( PCNA ) in theca and granulosa cells ( GC ) and an increase in the activation of
caspase 3 in antral follicles
Bhattacharya et al., Carcinogenesis 2012
(Neoplasm Invasiveness...) :
Furthermore, the anticancer activity of NAC-AITC is associated with the modulation of several important molecular targets, including downregulation of both a-tubulin and ß-tubulin,
activation of
caspase-3 and downregulation of
vascular endothelial growth factor
Zhao et al., Food Chem Toxicol 2012
(Liver Neoplasms, Experimental...) :
Additionally, we demonstrated that in transplanted tumor tissues, chrysin not only activated
caspase-3 and induced apoptosis, but also
inhibited the production of
vascular endothelial growth factor ( VEGF ) and suppressed angiogenesis