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LRP2 — SHH

Pathways - manually collected, often from reviews:

• KEGG Hedgehog signaling pathway: LRP2 → DHH/IHH/SHH (protein-protein, binding/association)
• NCI Pathway Database Signaling events mediated by the Hedgehog family: SHH Np/Cholesterol complex (SHH) → SHH Np/Cholesterol/Megalin complex (SHH-LRP2) (modification, collaborate)
  McCarthy et al., J Biol Chem 2002*
  Evidence: assay, other species
• NCI Pathway Database Signaling events mediated by the Hedgehog family: SHH Np/Cholesterol complex (SHH) → Megalin (LRP2) (modification, collaborate) McCarthy et al., J Biol Chem 2002*
  Evidence: assay, other species
• NCI Pathway Database Signaling events mediated by the Hedgehog family: SHH Np/Cholesterol complex (SHH) → Megalin/LRPAP1 complex (LRP2-LRPAP1) (modification, collaborate)
  McCarthy et al., J Biol Chem 2002*
  Evidence: assay, other species
• NCI Pathway Database Signaling events mediated by the Hedgehog family: LRPAP1 (LRPAP1) → SHH Np/Cholesterol/Megalin complex (SHH-LRP2) (modification, collaborate)
  McCarthy et al., J Biol Chem 2002*
  Evidence: assay, other species
• NCI Pathway Database Signaling events mediated by the Hedgehog family: SHH Np/Cholesterol/Megalin complex (SHH-LRP2) → Megalin (LRP2) (modification, collaborate) McCarthy et al., J Biol Chem 2002*
  Evidence: assay, other species
• NCI Pathway Database Signaling events mediated by the Hedgehog family: SHH Np/Cholesterol/Megalin complex (SHH-LRP2) → Megalin/LRPAP1 complex (LRP2-LRPAP1) (modification, collaborate)
  McCarthy et al., J Biol Chem 2002*
  Evidence: assay, other species

Text-mined interactions from Literome

McCarthy et al., J Cell Sci 2003 : The importance of Shh and RA signaling in neurodevelopment, combined with the fact that megalin-deficient mice show profound neurodevelopmental abnormalities, has raised questions as to the possible role of megalin in Shh and RA signaling
Christ et al., Dev Cell 2012 : Our data identify a critical role for LRP2 in SHH signaling and reveal the molecular mechanism underlying forebrain anomalies in mice and patients with Lrp2 defects