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CDH1 — TINF2

Text-mined interactions from Literome

Balzac et al., J Cell Sci 2005 : Here, we demonstrate that the small GTPase Rap1 , a crucial regulator of the inside-out activation of integrins, is a target for E-cadherin mediated outside-in signaling ... Furthermore, we demonstrate that the E-cadherin endocytosis dependent activation of Rap1 is associated with and controlled by an increased Src kinase activity, and is paralleled by the colocalization of Rap1 and E-cadherin at the perinuclear Rab11 positive recycling endosome compartment, and the association of Rap1 with a subset of E-cadherin-catenin complexes that does not contain p120ctn ... Finally, we demonstrate that the E-cadherin endocytosis dependent activation of Rap1 is associated with and is required for the formation of integrin based focal adhesions
Retta et al., Eur J Cell Biol 2006 : This review focuses on recent findings on the involvement of the small GTPase Rap1 in the regulation of cadherin- and integrin dependent cell adhesion and signal transduction