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APOB — NFKB1

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Li et al., Biochem Biophys Res Commun 1999 : Treatment of cells with gamma-tocopherol attenuated ox-LDL mediated degradation of IkappaB and activation of NF-kappaB ( both P < 0.01 vs ox-LDL alone )
Zhu et al., Atherosclerosis 1999 : LDL itself does not increase NF-kappa B binding in endothelial cells ( ECs )
Li et al., Arterioscler Thromb Vasc Biol 2000 : The critical role of NF-kappaB activation became evident in experiments with antisense LOX-1, which abolished ox-LDL mediated NF-kappaB activation
Janabi et al., Arterioscler Thromb Vasc Biol 2000 (Arteriosclerosis) : Oxidized LDL induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte derived macrophages from CD36-deficient patients
Li et al., Circulation 2000 : Treatment of cells with the antioxidant alpha-tocopherol ( 10 to 50 micromol/L ) attenuated ox-LDL mediated degradation of IkappaBalpha and activation of NF-kappaB ( P65 ) and inhibited the upregulation of AT1R mRNA and protein
Nishio et al., Life Sci 2000 : The effect of ox-LDL on the transcriptional factor NF-kappaB activation was investigated by electrophoretic mobility shift assay ( EMSA ) ... Ox-LDL caused NF-kappaB activation in VSMCs ... Treatment by transfection of NF-kappaB decoy oligodeoxynucleotides ( ODN ), but not scramble ones, blunted the activation of NF-kappaB by ox-LDL and caused a significant further induction of ox-LDL induced apoptosis
Ho et al., Phytomedicine 2001 (Arteriosclerosis) : Oxidation of low-density lipoprotein (LDL) and activation of the pleiotropic transcription factor nuclear factor kappa B (NF-kappaB) , are often the chemical and molecular alterations associated with the development of the atherosclerotic lesion
Ares et al., BMC immunology 2002 : In contrast, oxidized LDL stimulated AP-1 and PPARgamma but inhibited NF-kappaB , indicating that the effects of lipid loading with ac-LDL were not due to oxidation of lipids
Cominacini et al., Am J Hypertens 2002 : Ox-LDL and TNF-alpha increased the activation of NF-kappaB and the preincubation of HUVECs with zofenoprilat, but not with enalaprilat, dose dependently reduced its activation ( P < .001 )
Sonoki et al., Metabolism 2003 (Arteriosclerosis...) : Moreover, LDL isolated from diabetics contained more lyso-PC than that from nondiabetic subjects, and induced higher MCP-1 mRNA expression and NF-kappaB activity in HUVEC ... Preincubation with 4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide, a NO donor, abrogated increased expression of MCP-1 mRNA and high NF-kappaB activity induced by PLA2 treated LDL and by LDL isolated from diabetic patients
Ziouzenkova et al., J Biol Chem 2003 (Inflammation) : Here we demonstrate that LDL ( - ) increases tumor necrosis factor alpha (TNFalpha) induced inflammatory responses through NF kappa B and AP-1 activation with corresponding increases in vascular cell adhesion molecule-1 ( VCAM1 ) expression ... LPL treated LDL ( - ) suppressed NF kappa B and AP-1 activation, increasing expression of the PPAR alpha target gene I kappa B alpha, although only in the genetic presence of PPAR alpha and with intact LPL hydrolysis
Yin et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2001 : [ Effect of mm-LDL on NF-kB activation in endothelial cell ] ... mm-LDL may activate NF-kB through NIK-IKK beta pathway and promote PDGFb mRNA expression in endothelial cells
Zhou et al., Zhonghua Bing Li Xue Za Zhi 2003 (Arteriosclerosis...) : To detect whether the activation of nuclear factor-kappa B (NF-kappaB) in endothelial cells induced by mm-LDL can promote platelet derived growth factor-B ( PDGF-B ) expression in vitro, and whether it is also present in hypercholesterolemic rats in vivo, influence of age on NF-kappaB and PDGF-B signal transduction pathway
Lan et al., Chin Med J (Engl) 2004 : NF-kappa B was activated by Ox-LDL persistently and rebounded in the early period ... Ox-LDL induced NF-kappa B activation in a dose dependent way ... Ox-LDL induced activation of NF-kappa B persistently
Eisele et al., J Cardiovasc Pharmacol 2004 : LDL induced activation of the transcription factor NF-kappaB was inhibited by ASA, and ferritin protein was increased when endothelial cells were incubated with this drug
Nishimura et al., Osteoarthritis Cartilage 2004 : ox-LDL binding to LOX-1 in BACs increased the production of intracellular ROS and activated NF-kappaB
Cai et al., Circulation 2004 (Cardiovascular Diseases...) : In addition, Db-HAGE-LDL stimulated NF-kappaB activity significantly in ECV 304 and human umbilical vein endothelial cells ( 2.3-fold above baseline ) in a manner inhibitable by a MEK inhibitor PD98059 ( 10 micromol/L ), the antioxidant N-acetyl-l-cysteine, NAC ( 30 mmol/L ), and the NADPH oxidase inhibitor DPI ( 20 micromol/L )
Blázovics et al., Orv Hetil 2004 (Inflammatory Bowel Diseases) : It became known, that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of TNF-alpha and interleukin-1beta in macrophages as well as oxidized LDL modulates activation of NF-kappaB in mononuclear phagocytes by altering the degradation of I-kappaBs
Zhang et al., Chin Med Sci J 2005 : Effect of oxidized-LDL on NF-kappaB nuclear translocation in aortic smooth muscle cells originated from rats of different ages
Cominacini et al., J Am Coll Cardiol 2005 (Angina, Unstable) : In in vitro studies, the effect of ox-LDL and of the sera derived from a subgroup of UA patients and control subjects on monocytic NF-kB activation was also evaluated ... In the in vitro studies, ox-LDL dose-dependently increased the activation of NF-kB in monocytes, but not in lymphocytes derived from healthy volunteers
Hakala et al., Arterioscler Thromb Vasc Biol 2006 (Inflammation) : H-LDL induced rapid phosphorylation of the p38 mitogen activated protein kinase ( MAPK ), nuclear translocation of 2 transcription factors, nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1), and time dependent secretion of IL-8 from the macrophages
Wahyudi et al., Acta Med Indones 2007 (Arteriosclerosis) : Green tea polyphenols inhibit oxidized LDL induced NF-KB activation in human umbilical vein endothelial cells
Sonoki et al., Br J Pharmacol 2008 : MCP-1 mRNA expression and NF-kappaB activity were enhanced by venom sPLA2 treated LDL , which was completely suppressed by indoxam but not by thioetheramide-PC, a competitive sPLA2 inhibitor
Zhang et al., J Mol Endocrinol 2008 (Inflammation) : PEDF also attenuated the HOG-LDL induced NF-kappaB activation, suggesting that the inhibitory effect of PEDF on MCP-1 was at least partially through the blockade of NF-kappaB activation
Fenske et al., Thromb Haemost 2008 (Inflammation) : Production of endothelial IL-8 and simultaneous modulation of NF-kappaB in response to hydrolyzed LDL might serve to protect the vessel wall and promote silent removal of the insudated lipoprotein
Boyanovsky et al., Cytokine 2010 : Indirect immunofluorescence showed that GV-LDL but not control-LDL induced nuclear translocation of NFkappaB ... Inhibitors of NFkappaB activation, effectively blocked cytokine production induced by GV-LDL
Ares et al., Arterioscler Thromb Vasc Biol 1995 : In contrast, the radical dependent transcription factor nuclear factor-kappa B (NF-kappa B) was not activated by Ox-LDL, and at a concentration of 50 micrograms/mL, Ox-LDL inhibited lipopolysaccharide induced activation of NF-kappa B
Peng et al., J Biol Chem 1995 : Electrophoretic mobility shift assays demonstrated that activation of NF-kappa B by L-NMA, ox-LDL , and TNF alpha was attenuated by GSNO and SNP, but not by glutathione or cGMP analogues
Maziere et al., Biochem Mol Biol Int 1996 : The effect of cupric ions or endothelial cell oxidized LDL on the transcription factor NF kappa B activation was investigated by electrophoretic mobility shift assay ... Oxidized LDL induced NF kappa B activation in fibroblasts, endothelial and smooth muscle cells
Hamilton et al., J Leukoc Biol 1998 (Inflammation) : Oxidized LDL modulates activation of NFkappaB in mononuclear phagocytes by altering the degradation if IkappaBs