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DES — IGF1

Text-mined interactions from Literome

Turner et al., Endocrinology 1992 : Uterus and liver served as positive and negative control tissues, respectively, for the effects of DES on IGF-I mRNA levels in OVX rats ; mRNA levels were increased in uterus and decreased in liver after hormone treatment
Czifra et al., Cell Signal 2006 : In human muscle, IGF-I stimulated proliferation and fusion of the cells and the expression of the differentiation marker desmin
Tomas et al., Biochem J 1991 (Diabetes Mellitus, Experimental...) : Des ( 1-3 ) IGF-I induced binding proteins, but had only a slight effect on measured IGF-I concentrations
Politis et al., Endocrine 1995 : Not unexpectedly, insulin-like growth factor (IGF)-I , Des ( 1-3 ) IGF-I and IGF-II increased mammary epithelial u-PA activity on a per cell basis and u-PA mRNA levels, thus, mimicking the effect of insulin
Tomas et al., Diabetes 1996 (Body Weight...) : Des ( 1-3 ) IGF-I increased liver glycogen additively with insulin but reduced glucosuria only when given with 5.6 nmol insulin per day, indicating the possibility of a facilitatory effect, perhaps via increased insulin sensitivity