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CEBPB — RELA
Pathways - manually collected, often from reviews:
-
KEGG Tuberculosis:
NFKB1/RELA
→
CEBPB/CEBPG
(gene expression, expression)
-
Reactome Reaction:
CEBPB
→
RELA
(indirect_complex)
Hartupee et al., J Biol Chem 2008, Kuilman et al., Cell 2008, Orjalo et al., Proc Natl Acad Sci U S A 2009, Lee et al., Mol Cell Biol 2010, Lee et al., J Biol Chem 2010, Libermann et al., Mol Cell Biol 1990, Shimizu et al., Mol Cell Biol 1990, Matsusaka et al., Proc Natl Acad Sci U S A 1993, Kunsch et al., Mol Cell Biol 1993, Stein et al., Mol Cell Biol 1993, Jimi et al., J Biol Chem 1996
-
Reactome Reaction:
CEBPB
→
RELA
(reaction)
Hartupee et al., J Biol Chem 2008, Kuilman et al., Cell 2008, Orjalo et al., Proc Natl Acad Sci U S A 2009, Lee et al., Mol Cell Biol 2010, Lee et al., J Biol Chem 2010, Libermann et al., Mol Cell Biol 1990, Shimizu et al., Mol Cell Biol 1990, Matsusaka et al., Proc Natl Acad Sci U S A 1993, Kunsch et al., Mol Cell Biol 1993, Stein et al., Mol Cell Biol 1993, Jimi et al., J Biol Chem 1996
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CEBPB
—
RELA
(physical association, affinity chromatography technology)
Zwergal et al., J Immunol 2006*
-
IRef Biogrid Interaction:
CEBPB
—
RELA
(physical association, affinity chromatography technology)
Weber et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
CEBPB
—
RELA
(direct interaction, pull down)
Xia et al., Int J Biochem Cell Biol 1997*
-
IRef Hprd Interaction:
CEBPB
—
RELA
(in vitro)
Weber et al., J Biol Chem 2003*, Xia et al., Int J Biochem Cell Biol 1997*
-
IRef Hprd Interaction:
CEBPB
—
RELA
(in vivo)
Weber et al., J Biol Chem 2003*, Xia et al., Int J Biochem Cell Biol 1997*
-
IRef Ophid Interaction:
CEBPB
—
RELA
(aggregation, confirmational text mining)
Xia et al., Int J Biochem Cell Biol 1997*
-
IRef Ophid Interaction:
CEBPB
—
RELA
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Georganas et al., J Immunol 2000
(Arthritis, Rheumatoid) :
Employing gel shift assays, NF-kappaB,
C/EBPbeta , and c-Jun were constitutively activated in RA FLS, but only
NF-kappaB and c-Jun activity
increased after IL-1beta
Jana et al., J Neurochem 2002
:
Taken together, these studies suggest that activation of both NF-kappaB and
C/EBPbeta is important for strong induction of TNF-alpha and that CD40 ligation
regulates the expression of TNF-alpha by modulating the activation of only
NF-kappaB but not that of C/EBPbeta
Webb et al., J Dent Res 2002
(Osteosarcoma) :
Transfection of NFkappaB and C/EBPbeta-sensitive reporter promoter constructs demonstrated that
NFkappaB activity was enhanced and that constitutive
C/EBPbeta was
inhibited by TNF-alpha, with both effects being p38 MAPK dependent
Hoshino et al., J Exp Med 2002
(HIV Infections...) :
This is associated with loss of an inhibitory
CCAAT enhancer binding protein beta ( C/EBPbeta ) transcription factor and
activation of
nuclear factor (NF)-kappaB
Nakata et al., Kekkaku 2002
(HIV Infections...) :
Reduction of expression of an inhibitory
C/EBP beta transcription factor and
activation of
NF-kappa B are observed at the site of inflammation
Kravchenko et al., J Biol Chem 2003
(Inflammation) :
This link includes an
NF-kappaB dependent regulation of
C/EBPbeta and C/EBPdelta gene transcription and IKKi mediated activation of C/EBP
Zhu et al., J Biol Chem 2003
:
Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid dependent activation of AP-1 and
nuclear factor (NF)-IL-6 and prostanoid independent
activation of
NF-kappaB
Radoja et al., Mol Cell Biol 2004
(Epidermolysis Bullosa) :
We found that
C/EBP-beta and AP-1 induced, while retinoic acid, glucocorticoid receptors, and
NF-kappaB suppressed , the K15 promoter, along with other keratin gene promoters
Auch et al., FEBS Lett 2004
:
This study delineates a novel role of dsRNA in inducing the expression of iNOS through dsRNA activated protein kinase ( PKR ) -mediated activation of
NF-kappaB and p38 mediated
activation of
C/EBPbeta in human astroglia that may participate in virus induced neurological abnormalities
Kim et al., Biochem Biophys Res Commun 2005
:
Taken together, these results suggest that 8HQ acts to inhibit inflammation through inhibition of NO production and iNOS expression through blockade of
C/EBPbeta DNA binding activity and
NF-kappaB activation
Zwergal et al., J Immunol 2006
:
C/EBP beta blocks p65 phosphorylation and thereby
NF-kappa B-mediated transcription in TNF-tolerant cells
Patel et al., J Biol Chem 2007
:
These results, confirmed in primary human hepatocytes and CASMC, demonstrate for the first time that IL-17 is a potent inducer of CRP expression via p38 MAPK and ERK1/2 dependent
NF-kappaB and
C/EBPbeta activation and suggest that IL-17 may mediate chronic inflammation, atherosclerosis, and thrombosis
Du et al., J Immunol 2009
:
CsA and FK506, as well as other UPR inducers, caused up-regulation of C/EBP family members, especially C/EBPbeta and CHOP ( C/EBP homologous protein ), and overexpression of either
C/EBPbeta or CHOP significantly
attenuated TNF-alpha triggered
NF-kappaB activation
Cappello et al., Cell Signal 2009
:
This was accompanied by elevated nuclear p65 and
NF-kappaB activity in the
presence of
C/EBPbeta
Yu et al., J Biol Chem 2009
(Inflammation...) :
In addition, IDR-1
induced p38 MAPK activity in a p62 dependent manner and increased
CCAAT-enhancer binding protein beta activity, whereas
NF-kappaB activity was unaffected
Hayakawa et al., J Am Soc Nephrol 2010
:
Overexpression of
C/EBPbeta markedly
suppressed TNF-alpha induced activation of
NF-kappaB , independent of its transacting potential