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Text-mined interactions from Literome

Ueda et al., Antioxid Redox Signal 2002 (Necrosis) : Trx inhibits apoptosis signaling not only by scavenging intracellular ROS in cooperation with the GSH system, but also by inhibiting the activity of ASK1 and p38
Kunchithapautham et al., Infect Immun 2003 : Overexpression of Bm-TRX-1 in a human monocyte cell line negatively regulated tumor necrosis factor alpha induced p38 mitogen activated protein kinase activity, suggesting a possible role of the 16-kDa Bm-TRX-1 in immunomodulation
Yang et al., Microbes Infect 2010 : Japanese encephalitis virus down-regulates thioredoxin and induces ROS mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells
Shinkai et al., Chem Res Toxicol 2012 : Trx is a negative regulator of apoptosis signal regulating kinase 1 ( ASK1 ), and under the conditions of the experiment, 1,2-NQ activated ASK1 and p38 , leading to PARP cleavage and apoptotic cell death that were blocked by pretreatment with polyethylene glycol-catalase