UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to PLK1

BORA — PLK1

Pathways - manually collected, often from reviews:

NCI Pathway Database PLK1 signaling events: Aurora A/BORA complex (AURKA-BORA) → PLK1 (PLK1) (modification, activates) Macůrek et al., Nature 2008
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database PLK1 signaling events: Aurora A/BORA complex (AURKA-BORA) → PLK1 (PLK1) (modification, activates) Seki et al., Science 2008, Macůrek et al., Nature 2008
Evidence: mutant phenotype, assay, physical interaction
Reactome Reaction: PLK1 → BORA (reaction) Jang et al., J Biol Chem 2002, Hutterer et al., Dev Cell 2006, Seki et al., J Cell Biol 2008, Seki et al., Science 2008, Macůrek et al., Nature 2008
Reactome Reaction: PLK1 → BORA (direct_complex)
Reactome Reaction: PLK1 → BORA (indirect_complex) Hutterer et al., Dev Cell 2006, Seki et al., Science 2008

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: BORA — PLK1 (physical association, affinity chromatography technology) Seki et al., J Cell Biol 2008
IRef Biogrid Interaction: BORA — PLK1 (physical association, affinity chromatography technology) Svendsen et al., Cell 2009
IRef Dip Interaction: Complex of PLK1-AURKA-BORA (anti tag coimmunoprecipitation) Macůrek et al., Nature 2008
IRef Dip Interaction: BORA — PLK1 (physical association, anti tag coimmunoprecipitation) Macůrek et al., Nature 2008
IRef Intact Interaction: Complex of 24 proteins (association, anti tag coimmunoprecipitation) Svendsen et al., Cell 2009
IRef Intact Interaction: Complex of 26 proteins (physical association, tandem affinity purification) Hutchins et al., Science 2010

Text-mined interactions from Literome

Eckerdt et al., Trends Biochem Sci 2008 : During mitosis, Plk1 dependent Bora degradation promotes Aurora A localization to the centrosome and/or spindle
van Leuken et al., PloS one 2009 : Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora