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RHO — WNT1
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Habas et al., Cell 2001
:
Wnt/Frizzled activation of
Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1 ... Here we report that in human cells and during Xenopus embryogenesis,
Wnt/Fz signaling
activates the small GTPase
Rho , a key regulator of cytoskeleton architecture ...
Wnt/Fz activation of
Rho requires the cytoplasmic protein Dishevelled ( Dvl ) and a novel Formin homology protein Daam1 ... Daam1 binds to both Dvl and Rho, and mediates
Wnt induced
Dvl-Rho complex formation ... Inhibition or depletion of Daam1 prevents
Wnt/Fz activation of
Rho and of Xenopus gastrulation, but not of beta-catenin signaling
Habas et al., Genes Dev 2003
:
We demonstrated previously that
Wnt/Fz activation of
Rho , a GTPase and regulator of cytoskeletal architecture, is essential for vertebrate gastrulation ... Dishevelled ( Dvl ), a cytoplasmic protein downstream of Fz, forms a Wnt induced complex with Rac independent of the
Wnt induced
Dvl-Rho complex
Kishida et al., Mol Cell Biol 2004
:
The expression of Dvl-1,
Wnt-1 , or Wnt-3a
activated Rho-kinase in COS cells, and this activation was inhibited by the Rho binding domain of Rho-kinase
Habas et al., Methods Enzymol 2006
:
Activation of
Rho and Rac by
Wnt/frizzled signaling ... In this chapter, we describe biochemical assays for the detection of
Wnt/Fz activation of
Rho and Rac in both mammalian cells and Xenopus embryo explants
Mezzacappa et al., Methods Mol Biol 2012
:
The Rho family of small GTPases are activated and required for non-canonical Wnt signaling during gastrulation, and in this chapter, we describe biochemical assays for the detection of
Wnt mediated activation of
Rho , Rac, and Cdc42 in both mammalian cells and Xenopus embryo explants
Bannai et al., Frontiers in cellular and infection microbiology 2012
:
Our results reveal new details of the pathways involved in dermonecrotic toxin action on adipocyte differentiation, and the
role of
Rho/ROCK signaling in mediating toxin effects on
Wnt/ß-catenin and Notch1 signaling, and in particular the role of G ( q ) and G ( 12/13 ) in mediating PMT effects on Rho/ROCK and Notch1 signaling