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ETS1 — MAPK1
Pathways - manually collected, often from reviews:
-
KEGG Dorso-ventral axis formation:
MAPK1/MAPK3
→
ETS1/ETS2
(protein-protein, phosphorylation)
-
KEGG Pathways in cancer:
MAPK1/MAPK3
→
ETS1
(protein-protein, activation)
-
KEGG Renal cell carcinoma:
MAPK1/MAPK3
→
ETS1
(protein-protein, activation)
-
Reactome Reaction:
ETS1
→
MAPK1
(reaction)
Jayaraman et al., J Biol Chem 1999*, Seidel et al., Genes Dev 2002*, Foulds et al., Mol Cell Biol 2004*, Nelson et al., Proc Natl Acad Sci U S A 2010*, Yang et al., Mol Cell Biol 1996*
-
WikiPathways Apoptosis-related network due to altered Notch3 in ovarian cancer:
MAPK1
→
ETS1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Berti-Mattera et al., J Neurochem 2000
:
Similar
effects of
ETs on AA release and
MAPK activity were observed in cultures expanded from primary SC and in iSC
Foulds et al., Mol Cell Biol 2004
:
Ras/mitogen activated protein kinase signaling
activates Ets-1 and Ets-2 by CBP/p300 recruitment
Beh et al., Development 2007
:
In ascidian embryos,
FGF/MAPK mediated activation of the transcription factor
Ets1/2 is required for heart tissue specification and cell migration
Ghosh et al., J Biol Chem 2012
(MAP Kinase Signaling System...) :
Therefore, based on these observations, it is hypothesized that the
activation of PI3K/AKT and p38
MAPK by VEGF results in
ETS-1 gene expression, which activates MMP-9 and MMP-13, leading to the invasion and scattering of SKOV-3 cells
Woznica et al., Dev Biol 2012
:
The Ciona heart progenitor lineage is first specified by Fibroblast Growth Factor/Map Kinase (
FGF/MapK )
activation of the transcription factor
Ets1/2 ( Ets )