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HRH1 — IL4
Text-mined interactions from Literome
Sonobe et al., Inflamm Res 2004
:
Depletion of the
H1R resulted in decreases in the release of IL-2 and IL-10 from both CD4+ and CD8+ cells and increases in the release of
IL-4 from CD4+ T cells and IFN-gamma from CD8+ cells
Horio et al., Naunyn Schmiedebergs Arch Pharmacol 2010
:
IL-4 stimulation
increased H1R protein levels and H1R mRNA levels ...
IL-4 also
increased H1R promoter activity, but had no effect on H1R mRNA stability, indicating that up-regulation of H1R was due to an increase in H1R mRNA synthesis ... These results indicated that
IL-4 up-regulated
H1R mRNA level through increased transcription of H1R gene via JAK3-STAT6 pathway