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BCL2 — TFAP2A

Text-mined interactions from Literome

Wajapeyee et al., J Biol Chem 2006 : In addition, we show that AP-2alpha transcriptionally represses Bcl-2 by binding to its promoter both in vitro and in vivo and that this is essential for AP-2alpha induced apoptosis as ectopic expression of Bcl-2 efficiently inhibited apoptosis induced by AP-2alpha
Zhuang et al., Mod Pathol 2007 (Disease Progression...) : The results were also consistent with a role for AP-2 and MITF in regulation of Bcl-2 and pStat3 in regulation of Bcl-XL
Zhang et al., J Mol Histol 2012 : AP-2a dependent regulation of Bcl-2/Bax expression affects apoptosis in the trophoblast ... However, it is not clear whether AP-2a affects apoptosis in trophoblast cells and whether it regulates expression of apoptosis related factors Bcl-2 and Bax ... Furthermore, overexpression of AP-2a increased Bax expression and decreased Bcl-2 expression, whereas down-regulation of AP-2a expression resulted in a decrease in Bax expression and an increase in Bcl-2 expression ... AP-2a regulates expression of Bcl-2 and Bax and apoptosis in BeWo cells ... These results suggest that AP-2a mediated regulation of Bcl-2 and Bax regulation influences apoptosis which in turn leads to the pathogenesis of preeclampsia