Sun et al., Inflamm Res 2001
:
CD44 mediated cyclooxygenase-2 expression and thromboxane A2 production in RAW 264.7 macrophages
Dohadwala et al., J Biol Chem 2002
(Carcinoma, Non-Small-Cell Lung...) :
Genetic inhibition of tumor COX-2 led to diminished matrix metalloproteinase (MMP)-2, CD44 , and EP4 receptor expression and invasion
Murphy et al., FASEB J 2005
:
Here we show that engagement of CD44 with signaling monoclonal antibodies ( mAbs ) or its natural ligand hyaluronic acid induces COX-2 and prostacyclin ( PGI2 ) formation in human EC