◀ Back to MAPK7
F2RL1 — MAPK7
Text-mined interactions from Literome
Hirota et al., Hum Reprod 2005
(Endometriosis...) :
Activation of
PAR2 stimulated the phosphorylation of all three MAPK, and inhibitors of each
MAPK suppressed the PAR2 activation induced proliferation of ESC
Matsushima et al., Am J Physiol Lung Cell Mol Physiol 2006
(MAP Kinase Signaling System) :
These results indicate that HAT stimulates fibroblast proliferation in bronchial airways through a
PAR-2 dependent
MEK-MAPK mediated pathway and that HAT is linked to airway processes involving fibroblasts
Syeda et al., J Biol Chem 2006
:
PAR-1 and
PAR-2 stimulation rapidly
activated both ERK1/2 and
p38MAPK , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation
Pan et al., Shock 2008
:
Western blotting analysis showed that
PAR2-AP induced phosphorylation of p38
MAPK and its upstream protein kinase MAPK kinase 3/6 ( MKK3/6 ) in a time dependent manner
Namkung et al., Am J Physiol Gastrointest Liver Physiol 2008
(Pancreatitis) :
Effects of
PAR2 activation on intrapancreatic damage and on
mitogen activated protein ( MAP ) kinase signaling were assessed
Shi et al., Zhonghua Zhong Liu Za Zhi 2009
(Colonic Neoplasms) :
Factor VIIa and
PAR2-AP induced IL-8 expression at both mRNA and protein levels, upregulated TF mRNA expression and TF activity, but
down-regulated caspase-7 mRNA and p-p38
MAPK levels in SW620 cells
Flynn et al., J Biol Chem 2011
(Calcium Signaling...) :
All peptidomimetic agonists stimulated
PAR(2) dependent in vitro physiological responses,
MAPK signaling, and Ca ( 2+ ) signaling with an overall rank order of potency of 2-f-LIGRLO-NH ( 2 ) ˜ 2-at-LIGRL-NH ( 2 ) > 6-an-LIGRL-NH ( 2 ) » SLIGRL-NH ( 2 )
Saito et al., Hum Reprod 2011
(Endometriosis...) :
The TGF-ß1 induced increase in
PAR2 gene expression was
repressed by inhibition of p38
MAPK , p42/44 MAPK or PI3K, but not by knockdown of Smad4 expression
Ramachandran et al., J Biol Chem 2011
(Calcium Signaling...) :
Interestingly, elastase ( but neither cathepsin-G nor proteinase-3 ) causes a TL-independent
PAR(2) mediated
activation of
MAPK that, unlike the canonical trypsin activation, does not involve either receptor internalization or recruitment of ß-arrestin
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012
:
Although
PAR(2) activation
increased ERK
MAPK phosphorylation, neither ERK pathway inhibitors nor a p38 MAPK inhibitor affected 2fLI induced COX-2 expression
Zhang et al., Cell Physiol Biochem 2012
(MAP Kinase Signaling System) :
Inhibition of
PAR-2 suppressed tryptase induced ERK and p38
MAPK pathway activation in microglia