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PTH — TGFB1
Text-mined interactions from Literome
Wu et al., J Bone Miner Res 2000
:
Parathyroid hormone regulates
transforming growth factor beta1 and beta2 synthesis in osteoblasts via divergent signaling pathways
Sanders et al., Endocrinology 2000
(Bone Neoplasms...) :
Secretion of
PTH related peptide (PTHrP) from breast cancer cells is thought to play a key role in osteolytic metastases and is
increased by
transforming growth factor-beta ( TGFbeta ), which is released from resorbed bone
Seitz et al., J Bone Miner Res 1992
(Osteosarcoma) :
Effect of
transforming growth factor beta on
parathyroid hormone receptor binding and cAMP formation in rat osteosarcoma cells
Sowa et al., Cancer Res 2004
(Hyperparathyroidism, Secondary...) :
Here we have investigated the
roles of
transforming growth factor ( TGF ) -beta and menin, the product of the multiple endocrine neoplasia type 1 ( Men1 ) gene, in the proliferation and
PTH production of parathyroid cells from either patients with secondary hyperparathyroidism or Men1
Kwok et al., J Cell Biochem 2005
:
PTH also
stimulated TGF-beta1 mRNA expression in rat primary osteoblastic cells, indicating a link between systemic and local factors for intracellular signaling in osteoblasts ... We further examined the signaling pathways responsible for
PTH stimulated LTBP-1 and
TGF-beta1 mRNA expression in UMR 106-01 cells
Naito et al., Endocrine 2006
(Hypercalcemia...) :
The proband 's cultured parathyroid cells lacked the normal reduction in proliferation and
parathyroid hormone secretion in
response to
transforming growth factor- beta
Yamaguchi et al., J Cell Biol 1991
:
TGF-beta 1 induced neither
PTH responsiveness nor osteocalcin production in C26 cells, but it increased PTH responsiveness in C20 cells
Qiu et al., Nat Cell Biol 2010
:
Here we show that
transforming growth factor ( TGF)-beta type II receptor (TbetaRII ) forms an endocytic complex with PTH1R in
response to
PTH and regulates signalling by PTH and TGF-beta
McCauley et al., J Bone Miner Res 1995
:
Effects of differentiation and
transforming growth factor beta 1 on
PTH/PTHrP receptor mRNA levels in MC3T3-E1 cells
McCauley et al., Mol Cell Endocrinol 1994
(Osteosarcoma) :
Transforming growth factor-beta1 regulates steady-state
PTH/PTHrP receptor mRNA levels and PTHrP binding in ROS 17/2.8 osteosarcoma cells ... These data indicate that
TGF-beta1 upregulates steady-state mRNA, ligand binding and
PTH/PTHrP receptor signaling in rat osteosarcoma cells
Lacroix et al., Cancer Lett 1998
(Breast Neoplasms) :
The production of Il-11 was
increased by
transforming growth factor-beta1 in a dose dependent manner with a rapid ( 2 h ) and transient ( 24 h ) mRNA induction, but not by epidermal growth factor, insulin-like growth factor-I and -II, basic fibroblast growth factor, platelet derived growth factor or
parathyroid hormone