Gene interactions and pathways from curated databases and text-mining

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PTH — TGFB1

Text-mined interactions from Literome

Wu et al., J Bone Miner Res 2000 : Parathyroid hormone regulates transforming growth factor beta1 and beta2 synthesis in osteoblasts via divergent signaling pathways
Sanders et al., Endocrinology 2000 (Bone Neoplasms...) : Secretion of PTH related peptide (PTHrP) from breast cancer cells is thought to play a key role in osteolytic metastases and is increased by transforming growth factor-beta ( TGFbeta ), which is released from resorbed bone
Seitz et al., J Bone Miner Res 1992 (Osteosarcoma) : Effect of transforming growth factor beta on parathyroid hormone receptor binding and cAMP formation in rat osteosarcoma cells
Sowa et al., Cancer Res 2004 (Hyperparathyroidism, Secondary...) : Here we have investigated the roles of transforming growth factor ( TGF ) -beta and menin, the product of the multiple endocrine neoplasia type 1 ( Men1 ) gene, in the proliferation and PTH production of parathyroid cells from either patients with secondary hyperparathyroidism or Men1
Kwok et al., J Cell Biochem 2005 : PTH also stimulated TGF-beta1 mRNA expression in rat primary osteoblastic cells, indicating a link between systemic and local factors for intracellular signaling in osteoblasts ... We further examined the signaling pathways responsible for PTH stimulated LTBP-1 and TGF-beta1 mRNA expression in UMR 106-01 cells
Naito et al., Endocrine 2006 (Hypercalcemia...) : The proband 's cultured parathyroid cells lacked the normal reduction in proliferation and parathyroid hormone secretion in response to transforming growth factor- beta
Yamaguchi et al., J Cell Biol 1991 : TGF-beta 1 induced neither PTH responsiveness nor osteocalcin production in C26 cells, but it increased PTH responsiveness in C20 cells
Qiu et al., Nat Cell Biol 2010 : Here we show that transforming growth factor ( TGF)-beta type II receptor (TbetaRII ) forms an endocytic complex with PTH1R in response to PTH and regulates signalling by PTH and TGF-beta
McCauley et al., J Bone Miner Res 1995 : Effects of differentiation and transforming growth factor beta 1 on PTH/PTHrP receptor mRNA levels in MC3T3-E1 cells
McCauley et al., Mol Cell Endocrinol 1994 (Osteosarcoma) : Transforming growth factor-beta1 regulates steady-state PTH/PTHrP receptor mRNA levels and PTHrP binding in ROS 17/2.8 osteosarcoma cells ... These data indicate that TGF-beta1 upregulates steady-state mRNA, ligand binding and PTH/PTHrP receptor signaling in rat osteosarcoma cells
Lacroix et al., Cancer Lett 1998 (Breast Neoplasms) : The production of Il-11 was increased by transforming growth factor-beta1 in a dose dependent manner with a rapid ( 2 h ) and transient ( 24 h ) mRNA induction, but not by epidermal growth factor, insulin-like growth factor-I and -II, basic fibroblast growth factor, platelet derived growth factor or parathyroid hormone