Kim et al., Mol Cell Biol 2004
:
Jab1/CSN5 , a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation
Shi et al., FEBS Lett 2008
:
Overexpression of SOCS-1 in HMCs inhibited HG-induced JAK2/STAT activation, c-Fos/c-Jun expression, and increased synthesis of TGF-beta1 and fibronectin ... These data suggest that SOCS-1 inhibits HG-induced overexpression of TGF-beta1 and synthesis of fibronectin in HMC, which may be via JAK/STAT pathway