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MMP9 — SMAD3

Text-mined interactions from Literome

Kim et al., Invest Ophthalmol Vis Sci 2005 : To evaluate the effects of TGF-beta1 and doxycycline on production of gelatinase MMP-9 and activation of Smad , c-Jun N-terminal kinase (JNK), extracellular regulated kinase (ERK), and p38 mitogen activated protein kinase ( MAPK ) signaling pathways in human corneal epithelial cells
Okamoto et al., Biochem Biophys Res Commun 2009 (Cerebral Hemorrhage) : The TGF-beta1 induced MMP-9 expression was attenuated in the presence of either MEK or Smad 3 inhibitor
Gordon et al., J Cell Physiol 2009 : Our data suggest TGF-beta mediated MMP-9 induction may be regulated by the NF-kappaB, Smad3 , and JNK pathways, whereas the IL-1beta mediated induction may be regulated by the NF-kappaB and p38 pathways
Kim et al., Cancer Lett 2012 (Breast Neoplasms) : We also investigated the role of smad3 on EGF induced MMP-9 expression and showed that EGF induced MMP-9 expression was decreased by smad3 siRNA transfection, whereas EGF induced MMP-9 expression was further increased by smad3 over-expression, as expected ... This study showed that EGF induced smad3 phosphorylation mediates the induction of MMP-9 , whereas smad7 inhibits TGF-ß1 as well as the EGF signaling pathway in SKBR3 cells
Xu et al., Angiogenesis 2012 (Choroidal Neovascularization) : The inhibition of MMP-9 was Smad dependent because BMP4 failed to repress TNF induced MMP-9 expression when Smad1,5 was silenced by siRNA