◀ Back to RAC1
ITGB1 — RAC1
Pathways - manually collected, often from reviews:
-
BioCarta ucalpain and friends in cell spread:
RAC1
→
Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2)
(modification, activates)
-
BioCarta ucalpain and friends in cell spread:
RAC1
→
Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1)
(modification, activates)
-
NCI Pathway Database Syndecan-4-mediated signaling events:
RAC1/GDP complex (RAC1)
→
alpha5/beta1 Integrin complex (ITGA5-ITGB1)
(modification, collaborate)
Woods et al., Arch Biochem Biophys 2000, Tumova et al., J Biol Chem 2000, Mahalingam et al., J Biol Chem 2007, Bass et al., J Cell Biol 2007
Evidence: mutant phenotype, assay
-
WikiPathways Rac1/Pak1/p38/MMP-2 pathway:
RAC1
→
ITGB1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Rose et al., Immunol Rev 2007
:
We describe mechanisms through which
alpha4beta1 integrin signaling
regulates appropriate
Rac activation to drive leukocyte migration
Yap et al., Oncogene 2009
(Carcinoma, Squamous Cell...) :
We found that alphavbeta6- and
alpha5beta1-integrin dependent activation of
Rac1 was mediated through Eps8
Chai et al., Int J Mol Med 2010
:
Upon activation,
Rac1 increased surface
alpha6/beta1 integrin levels and promoted colony forming efficiency of ESCs
Cailleteau et al., J Cell Sci 2010
:
alpha2beta1 integrin controls association of
Rac with the membrane and triggers quiescence of endothelial cells