Izumi et al., Nucleic Acids Res 2000
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Mcm10 is a nuclear protein that is localized to replication origins and mediates the interaction of the Mcm2-7 complex with replication origins
Wohlschlegel et al., Mol Cell 2002
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Current models suggest that the replication initiation factor Mcm10 is required for association of Mcm2-7 with origins of replication to generate the prereplicative complex (pre-RC)
Gregan et al., Mol Biol Cell 2003
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However, unlike the situation in Xenopus, where Mcm10 chromatin binding is dependent on Mcm2-7 , we show that the fission yeast protein is bound to chromatin throughout the cell cycle in growing cells, and only displaced from chromatin during quiescence