Gene interactions and pathways from curated databases and text-mining

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CBL — CFTR

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ye et al., J Biol Chem 2010 : Small interfering RNA mediated silencing of c-Cbl increased CFTR expression in the plasma membrane by inhibiting CFTR endocytosis and increased CFTR mediated Cl ( - ) currents
Cihil et al., Communicative & integrative biology 2013 : c-Cbl reduces stability of rescued ?F508-CFTR in human airway epithelial cells : Implications for cystic fibrosis treatment ... Partial depletion of c-Cbl increased stability of the plasma membrane associated mature ?F508-CFTR and the ?F508-CFTR mediated Cl ( - ) secretion