◀ Back to EGF
EGF — ESR1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Apostolakis et al., Mol Endocrinol 2000
:
The potent mitogen
epidermal growth factor (EGF) activates
estrogen receptor ( ER ) -dependent transcription in cultured cells in the absence of exogenous E ... Using antisense oligonucleotides, pharmacological and antibody blockade, and mutant mice, we also report that this behavioral responsiveness is mediated through ERalpha by specific stimulation of membrane bound EGF receptors and
EGF receptor-specific tyrosine kinase rather than by direct ligand
activation of the
ERalpha
Martin et al., Endocrinology 2000
:
Stable transfection of cells with a dominant negative Akt mutant blocked the
effects of
EGF and IGF-I on
ER-alpha expression and activity, whereas stable transfection of cells with a constitutively active Akt mutant mimicked the effects of EGF and IGF-I
Biswas et al., Proc Natl Acad Sci U S A 2001
(Breast Neoplasms...) :
The effect of a kinase inhibitor Go6796 on growth of
epidermal growth factor (EGF) stimulated
estrogen receptor negative ( ER- ) breast cancer cells in vivo and role of nuclear factor kappa B (NF-kappaB) on tumorogenesis have been investigated
Migliaccio et al., Cancer Res 2005
(Breast Neoplasms...) :
Interestingly,
EGF triggers rapid association of Src with androgen receptor (AR) and
estradiol receptor alpha (ERalpha) in MCF-7 cells or ERbeta in LNCaP cells
Li et al., Endocrinology 2006
(MAP Kinase Signaling System) :
The effect is mediated by
estrogen receptor-alpha and
involves in part the
EGF-EGF receptor and ERK-MAPK cascades as proximal signaling networks and the CK2 and Rho associated kinase regulated myosin heavy chain phosphatase as terminal effectors
Jia et al., Nan Fang Yi Ke Da Xue Xue Bao 2006
(Prostatic Hyperplasia) :
To investigate the
effects of
epidermal growth factor (EGF) on
estrogen receptor ( ER ) and androgen receptor (AR) in mouse prostate cells and explore the putative role of EGF in prostatic hyperplasia
Green et al., Mol Cancer Res 2007
:
BTF3 interacts with
ERalpha that has been
activated either by 17beta-estradiol ( ligand dependent activation ) or by
epidermal growth factor ( ligand independent activation )
Berno et al., PloS one 2008
:
Activation of
estrogen receptor-alpha by E2 or
EGF induces temporally distinct patterns of large-scale chromatin modification and mRNA transcription
Chen et al., Am J Physiol Endocrinol Metab 2009
:
Both estrogen ( E2 ) and EGF regulate lactotrophs, and we recently demonstrated that
EGF phosphorylates S118 on estrogen receptor-alpha (ERalpha) and
requires ERalpha to stimulate prolactin (PRL) release
Galand et al., Endocrinology 1996
:
Considering reports from the literature showing that
EGF can directly
induce the phosphorylated active form of the
estrogen receptor , we speculate that this might implicate its action on cGMP, with the latter then intervening as cofactor of the involved phosphokinase ( s )
Bunone et al., EMBO J 1996
:
Activation of the unliganded
estrogen receptor by
EGF involves the MAP kinase pathway and direct phosphorylation
Curtis et al., Proc Natl Acad Sci U S A 1996
:
These studies have suggested a `` cross-talk '' model in which
EGF receptor (EGF-R) signaling
results in activation of nuclear
estrogen receptor ( ER ) and its target genes in an estrogen independent manner
Karas et al., J Clin Invest 1998
:
However, in vascular cells, we found that pharmacologic inhibition of MAP kinase did not alter
EGF mediated
ERalpha activation
Damien et al., J Bone Miner Res 1998
:
That both ICI 182,780 and tamoxifen, which in other tissues act as estrogen antagonists, should reduce osteoblast proliferation stimulated by 17beta-estradiol and EGF, but not that by FGF or the IGFs, was expected since the mitogenic
effects of estrogen and
EGF involve the
estrogen receptor , whereas those of FGF and the IGFs do not