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JAK2 — MCL1
Text-mined interactions from Literome
Epling-Burnette et al., J Immunol 2001
:
Cooperative
regulation of
Mcl-1 by
Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony stimulating factor delayed apoptosis in human neutrophils ... We examined the hypothesis that
Janus kinase/STAT and PI 3-kinase
regulation of
Mcl-1 contributed to GM-CSF delayed apoptosis
Song et al., Chin J Cancer 2002
(Multiple Myeloma) :
IL-6 inhibited apoptosis of XG-7 cells through up-regulation of
Mcl-1 and the
activation of
JAK/STAT rather than Ras/MAPK nor PI-3K/Akt signal transduction pathway
Wu et al., Chin J Cancer 2009
(Nasopharyngeal Neoplasms) :
This study was to investigate the
effects of a
JAK inhibitor, AG490, on the proliferation, apoptosis, and expressions of apoptosis related survivin and
Mcl-1 genes, thus to explore the role of JAK-STAT3 signaling pathway in the regulation of cell apoptosis in nasopharyngeal carcinoma (NPC) cell line CNE-2Z
Jiang et al., J Hepatol 2009
:
Mcl-1 expression was upregulated in a
JAK dependent manner
Chen et al., Cancer Lett 2010
(Leukemia, Erythroblastic, Acute...) :
Triptolide inhibits
Jak2 transcription and
induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3 mediated cleavage of
Mcl-1
Rubert et al., BMC cancer 2011
:
Bim activation following
JAK2 inhibition
led to enhanced sequestration of
Mcl-1 , besides Bcl-xL