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MMP9 — NA
Text-mined interactions from Literome
Kawakami et al., Anticancer Res 2001
(Neoplasm Invasiveness...) :
TPA increased the MMP-9 production by T24 cells without altering expression of TIMP-1 gene, while
NAC suppressed TPA enhanced production of
MMP-9 ... In vitro experiments demonstrated that
MMP-9 was directly
inhibited by
NAC but was not influenced by TPA
Ollivier et al., Am J Vet Res 2003
(Corneal Ulcer...) :
We documented that EDTA, doxycycline,
NAC , ilomostat, alpha1PI, and ES
inhibited MMP activity in vitro
Mizoguchi et al., J Neurochem 2007
:
On the other hand,
MMP-2/-9 inhibitors blocked the METH induced behavioral sensitization and conditioned place preference, a measure of the rewarding effect, and
reduced the METH increased dopamine release in the
NAc
Mizoguchi et al., J Pharmacol Sci 2008
(Amphetamine-Related Disorders...) :
MMP-2/-9 inhibitors blocked the METH induced behavioral sensitization and conditioned place preference (CPP), a measure of the rewarding effect of a drug, and
reduced the METH increased dopamine release in the
NAc
Voronkina et al., Tsitologiia 2008
(Cell Transformation, Viral) :
NAC action for 2-6 hours completely
inhibited MMP-2 and
MMP-9 activity in both cell lines
Radomska-Leśniewska et al., Pharmacol Rep 2010
(Lung Diseases, Interstitial...) :
Therefore, the aim of the present work was to evaluate the
effect of
NAC on interleukin-8 (IL-8) and
matrix metalloproteinase-9 (MMP-9) production as well as intercellular cell adhesion molecule-1 ( ICAM-1 ) expression by BAL cells from interstitial lung diseases
Popova et al., Antioxid Redox Signal 2010
:
The same effect was achieved by the nontargeted antioxidant Trolox at higher concentration, but the thiol antioxidant
N-acetylcysteine (NAC) inhibited
MMP activity and was not able to induce myofibroblast differentiation
Li et al., Chem Biol Interact 2010
:
DP increased the levels of reactive oxygen species ( ROS ) in HepG2 cells, and antioxidant
N-acetylcysteine (NAC) completely blocked DP-induced ROS accumulation and the disruption of the balance between Bax and Bcl-2 proteins, and effectively
blocked the decreased
MMP and apoptosis, but had no effect on the activation of caspase-8 and the up-regulations of DR4 and DR5 induced by DP
Lu et al., J Atheroscler Thromb 2011
(Plaque, Atherosclerotic) :
Moreover, we found that
NAC down-regulated the expression of VCAM-1,
MMP2 and MMP9, accompanied by inhibition of NF-?B activation and reduced expression of RAGE ... Moreover, we found that
NAC down-regulated the expression of VCAM-1, MMP2 and
MMP9 , accompanied by inhibition of NF-?B activation and reduced expression of RAGE
Ramaesh et al., Eye (Lond) 2012
:
Twenty mM
NAC inhibited the secretion of
MMP-9 significantly ... This study shows that
NAC reduces
MMP-9 production by HCE cells and inhibits cell migration in vitro
Zang et al., Int Immunopharmacol 2013
(Lymphoma, Large B-Cell, Diffuse...) :
Phagocytosis, the loss of
MMP , autophagy and the activated signaling pathways were all
suppressed by ROS scavenger
N-acetyl-l-cysteine (NAC) , HO scavenger catalase or OH scavenger glutathione ( GSH )