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A2M — LRPAP1

Text-mined interactions from Literome

Misra et al., J Biol Chem 1999 : Neither RAP nor Ni ( 2+ ) blocked the binding of ( 125 ) I-alpha(2)M* to alpha ( 2 ) MSR on insulin- or buffer treated cells, but they both blocked binding to LRP/alpha ( 2 ) MR. Insulin significantly increased LRP/alpha ( 2 ) MR mRNA levels in a dose- and time dependent manner
Chiabrando et al., J Neurosci Res 2002 : Data presented here show that RAP blocked the neurite- and Trk-inhibitory activities of both MA-PZP and MA-alpha(2)M , whereas RAP itself had no neuromodulatory effect
Williams et al., J Biol Chem 1992 : Heterologous ligand displacement experiments demonstrated that RAP completely inhibits the binding of 125I activated alpha 2M to human fibroblasts and to the purified alpha 2MR/LRP, with a Ki of 23 and 26 nM, respectively
Ziere et al., Eur J Biochem 1996 : We have investigated the effect of the 39-kDa receptor associated protein (RAP) on the recognition site for activated alpha 2-macroglobulin and beta-VLDL on rat liver parenchymal cells in vivo and in vitro in order to analyze whether both substrates are recognized and internalized by the same receptor system ... Binding studies with isolated liver parenchymal cells in vitro demonstrated that the binding of 125I-alpha 2M-T was 98 % inhibited by GST-RAP with an IC50 of 0.3 microgram/ml ( 4.2 nM ), whereas the binding of 125I-beta-VLDL and 125I-beta-VLDL + recombinant apolipoprotein E (rec-apoE) was unaffected by GST-RAP up to 50 micrograms/ml ( 700 nM ) ... Also, the cell association and degradation of alpha 2M-T was blocked by RAP , while the association and degradation of beta-VLDL and beta-VLDL + rec-apoE were not influenced ... The inhibitory effect of RAP on the cell association and degradation of alpha 2M-T lasted for 1-2 h of incubation at 37 degrees C