Gene interactions and pathways from curated databases and text-mining

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CA2 — CREB3

Text-mined interactions from Literome

Ledo et al., EMBO J 2002 : Ca2+ dependent block of CREB-CBP transcription by repressor DREAM ... Thus, Ca2+ dependent interactions between DREAM and CREB represent a novel point of cross-talk between cAMP and Ca2+ signalling pathways in the nucleus
Barlow et al., Am J Respir Cell Mol Biol 2006 : In this study, we tested the hypotheses that oxidants induce Ca2+ mediated phosphorylation of ERK and CREB , and that CREB is required for oxidant induced proliferation and apoptosis
Mathieson et al., Br J Pharmacol 2006 : Sphingolipids differentially regulate mitogen activated protein kinases and intracellular Ca2+ in vascular smooth muscle : effects on CREB activation
Huang et al., J Neurosci 2006 : These Ng-/- mice, as compared with Ng+/+, respond poorly after treatment of their hippocampal slices with agents that activate signaling molecules important for learning and memory, including Ca2+/calmodulin dependent protein kinase II ( alphaCaMKII ), PKC, protein kinase A (PKA), extracellular signal regulated kinase ( ERK ), and cAMP response element binding protein ( CREB )
Rosethorne et al., Biochem Pharmacol 2008 (Neuroblastoma...) : Removal of extracellular Ca2+ , inhibition of Ca2+/calmodulin dependent protein kinase II and down-regulation of protein kinase C ( PKC ) resulted in reduced CREB phosphorylation after both M3 mACh and B2 bradykinin receptor activation
Schwaninger et al., J Biol Chem 1995 : Gene transcription can be induced by cAMP and Ca2+ through distinct protein kinases phosphorylating the transcription factor CREB , which binds to cAMP response elements ( CREs ) in various genes
Matthews et al., Mol Cell Biol 1994 : In neurons and other cell types, CREB phosphorylation and activation of CRE containing promoters can occur in response to elevated intracellular Ca2+
Takuma et al., Biochem Mol Biol Int 1997 : Regulation of CREB phosphorylation by cAMP and Ca2+ in parotid acinar cells
Ahn et al., Mol Cell Biol 1998 : A-CREB completely inhibited cAMP mediated, but only partially inhibited Ca2+- and NGF mediated, transcription of a reporter gene containing 750 bp of the native c-fos promoter
Rajadhyaksha et al., Dev Neurosci 1998 : Here we present the role of N-methyl-D-aspartate receptors and Ca2+ in cyclic AMP mediated CREB phosphorylation
Duman et al., J ECT 1998 : Studies in vivo and in cultured cells indicate that the induction of BDNF and TrkB is mediated by the cyclic adenosine monophosphate ( cAMP ) response element binding protein ( CREB ), a transcription factor that is activated by cAMP and Ca2+ intracellular pathways
Impey et al., Neuron 1998 (Calcium Signaling) : The sequential activation of ERK and Rsk2 by Ca2+ leads to the phosphorylation and transactivation of CREB