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MPL — TYK2
Pathways - manually collected, often from reviews:
-
KEGG Jak-STAT signaling pathway:
CNTFR/CRLF2/CSF2RA/CSF2RB/CSF3R/EPOR/GHR/IFNAR1/IFNAR2/IFNGR1/IFNGR2/IFNLR1/IL10RA/IL10RB/IL11RA/IL12RB1/IL12RB2/IL13RA1/IL13RA2/IL15RA/IL20RA/IL20RB/IL21R/IL22RA1/IL22RA2/IL23R/IL2RA/IL2RB/IL2RG/IL3RA/IL4R/IL5RA/IL6R/IL6ST/IL7R/IL9R/LEPR/LIFR/MPL/OSMR/PRLR
→
JAK1/JAK2/JAK3/TYK2
(protein-protein, phosphorylation)
Text-mined interactions from Literome
Royer et al., J Biol Chem 2005
:
Here we show that, in addition to signaling downstream from the activated TpoR, JAK2 and
Tyk2 strongly promote cell surface localization and
enhance total protein levels of the
TpoR
Sattler et al., J Cell Physiol 1997
:
We have previously shown that activation of
c-MPL by thrombopoietin rapidly
activates at least two cytoplasmic tyrosine kinases, JAK2 and
TYK2 , after ligand binding