Gene interactions and pathways from curated databases and text-mining

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LEP — MC4R

Text-mined interactions from Literome

Watanobe et al., Biochem Biophys Res Commun 1999 : The melanocortin 4 receptor mediates leptin stimulation of luteinizing hormone and prolactin surges in steroid primed ovariectomized rats
Watanobe et al., J Neurochem 2003 : Pivotal roles of alpha-melanocyte stimulating hormone and the melanocortin 4 receptor in leptin stimulation of prolactin secretion in rats
Lubrano-Berthelier et al., J Clin Endocrinol Metab 2004 (Body Weight...) : In contrast, MC4R does not mediate the effect of leptin on linear growth and other endocrine axes
Wankhade et al., Mol Cell Endocrinol 2011 : Leptin induced transactivation of the Mc4r promoter is significantly higher in the presence of exogenously added Nhlh2