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CAPN14 — EGFR
Text-mined interactions from Literome
Shiraha et al., J Cell Biol 1999
:
IP-10 inhibits epidermal growth factor induced motility by decreasing
epidermal growth factor receptor mediated
calpain activity
Glading et al., J Biol Chem 2000
(MAP Kinase Signaling System) :
Epidermal growth factor receptor activation of
calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway
Glading et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
With differential ligand induced internalization and trafficking restricted receptor variants, we find that
calpain activity is
triggered only by plasma membrane restricted activated EGFR, not by internalized ( although still active )
EGFR
Allen et al., Wound Repair Regen 2002
:
The mitogen activated protein kinase kinase-1-selective inhibitor PD 98059 that blocks signaling through the extracellular signal regulated kinase/mitogen activated protein kinase pathway, required for
epidermal growth factor receptor mediated activation of
calpain and de-adhesion, does not significantly affect the magnitude of matrix contraction within minutes of epidermal growth factor addition, but slows the decay similarly to calpain inhibition ...
Epidermal growth factor receptor signaling thus stimulates the complementary mechanisms of intracellular contractile force generation and
calpain mediated de-adhesion, which are known to coordinately facilitate cell migration
Carragher et al., Int J Biochem Cell Biol 2002
(Cell Transformation, Neoplastic...) :
Src and
epidermal growth factor receptor (EGFR) stimulated cell motility is
dependent upon
calpain activation
Xu et al., Prostate 2011
(Prostatic Neoplasms) :
Loss of
EGFR also
increased the activity of
calpain , which is pro-apoptotic