Findling-Kagan et al., Leuk Res 2005
(Lymphoma) :
This cell variant expresses the human MDR1 and exhibits de novo functional Pgp activity that can be blocked by the Pgp-modulators VRP and KT-5720
He et al., Chin J Cancer 2008
(Stomach Neoplasms) :
However, verapamil (VRP) , the inhibitor of P-gp , can not totally reverse the drug resistance, indicating that additional mechanisms must contribute to the MDR phenotype